Document Detail


Twin trisomies-Edward and Patau syndromes.
MedLine Citation:
PMID:  18440001     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To report the rare occurrence of dichorionic diamniotic twins with dissimilar aneuploidies. DESIGN: Case report. SETTING: District general hospital. PATIENT(S): A 36-year-old woman conceived by in vitro fertilization. Dichorionic diamniotic twins were found to have elevated nuchal translucencies and cystic hygromas. Intrauterine deaths occurred at 13 and 17 weeks gestation. INTERVENTION(S): Medical termination of pregnancy. MAIN OUTCOME MEASURE(S): Karyotypes. RESULT(S): Cytogenetic studies confirmed Edward's and Patau's syndromes. CONCLUSION(S): The aetiology is unknown but maternal age and in vitro fertilization may be linked since the incidence of aneuploidy rises with maternal age and the incidence of twins' increases with assisted reproductive techniques. This case highlights the need for obstetricians to have good communication and counselling skills.
Authors:
Nadine Massiah; Emma Griffiths; Vincent Bamigboye
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-04-25
Journal Detail:
Title:  Fertility and sterility     Volume:  90     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-10     Completed Date:  2008-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2011.e23-4     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, Furness General Hospital, Barrow in Furness, United Kingdom. nsmassiah@doctors.org.uk
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Multiple / genetics*,  pathology
Abortion, Therapeutic
Adult
Age Factors
Female
Fertilization in Vitro / adverse effects*
Fetal Death / genetics*,  pathology
Gestational Age
Humans
Karyotyping
Lymphangioma, Cystic / genetics,  pathology
Nuchal Translucency Measurement
Pregnancy
Pregnancy, Multiple*
Syndrome
Trisomy*
Twins / genetics*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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