| Twin pregnancy with complete hydatidiform mole and coexistent fetus: obstetrical and oncological outcomes in a series of 14 cases. | |
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MedLine Citation:
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PMID: 19193484 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Twin pregnancy with complete hydatidiform mole and coexistent fetus (CHM&CF) is a rare situation and a challenge for diagnosis. Results related to fetal outcome and maternal risk of subsequent gestational trophoblastic neoplasia (GTN) are controversial. We here display a series from the French Trophoblastic Disease Reference Center, which is to date the third in number of cases registered by the same center. STUDY DESIGN: By retrospective method based on patients from the French Trophoblastic Disease Reference Center data base between November 1999 and December 2006, 17 assumed cases were reviewed. In 14 cases the diagnosis of CHM&CF was ascertained. All files were reviewed to confirm diagnosis. Methods of initial diagnosis, outcome of pregnancy and evolution to GTN were studied. RESULTS: In 10 cases (71%) diagnosis was made by ultrasonography. Differential diagnoses were partial hydatidiform mole and mesenchymal dysplasia. Three patients in 14 (21%) delivered a healthy child. In only one case, delivery occurred after 37 weeks of gestation. Seven patients (50%) had a diagnosis of GTN. No patient had fatal evolution. Clinical events, such as vaginal bleeding, pre-eclampsia or hyperthyroidism, had no effect on the evolution to GTN. Continuation of the pregnancy did not increase the risk of GTN. CONCLUSION: In case of prenatal diagnosis of CHM&CF, and even if delivery of a healthy child is possible, patients should be aware of a possibly higher risk of GTN than in CHM. |
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Authors:
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Jérôme Massardier; François Golfier; Dorothée Journet; Lucien Frappart; Marcel Zalaquett; Anne Marie Schott; Véronique Trillet Lenoir; Olivier Dupuis; Touria Hajri; Daniel Raudrant |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Twin Study Date: 2009-02-03 |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 143 ISSN: 1872-7654 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-17 Completed Date: 2009-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 84-7 Citation Subset: IM |
Affiliation:
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Université de Lyon, F-69622 Lyon, France. jerome.massardier@chu-lyon.fr |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Gestational Trophoblastic Neoplasms / epidemiology Humans Hydatidiform Mole / diagnosis* Pregnancy Pregnancy Complications, Neoplastic / diagnosis* Pregnancy Outcome* Retrospective Studies Risk Factors Twins* Ultrasonography, Prenatal Uterine Neoplasms / diagnosis* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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