Document Detail

Twin pregnancies complicated by a single malformed fetus: chorionicity, outcome and management.
MedLine Citation:
PMID:  20874474     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to evaluate the impact of one abnormal fetus in a twin pregnancy, to compare impact of chorionicity and clinical outcome of intervention and expectant management. Thirty-seven dichorionic (DC) twins and 18 monochorionic (MC) twins complicated with one malformed fetus were evaluated for gestational age, birthweight and perinatal outcome. Six hundred and forty-two twin pregnancies were evaluated in the database. The control groups consisted of 429 DC and 86 MC twins without anomalous fetus. Mean birthweight and gestational age at birth for DC control group were (n = 429; 2137g and 34.71 weeks), DC study group, n = 37; 2117g (p = .338) and 33.97 weeks (p = .311), and DC study group with major malformations, n = 30; 2019g (p = .289) and 33.3 weeks (p = .01), and showed only significance for gestational age. There was no statistical significance between MC control group, n = 86; 2097g and 34.93 weeks, and MC study group, n = 18; 2237g (p = .338), and 34.42 weeks (p = .502). Because of limited data, the preliminary evaluation for expectant management and intervention, and survival of at least one normal fetus showed no impact. We conclude that, although, all DC twin pregnancies have a risk for preterm delivery, DC twins complicated with major malformation of one twin, have a lower mean gestational age at birth. Preliminary results for intervention does not improve fetal outcome for DC and MC twins and needs further evaluation with greater studies of impact or review.
Ali Gedikbasi; Alpaslan Akyol; Gokhan Yildirim; Ali Ekiz; Ahmet Gul; Yavuz Ceylan
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Publication Detail:
Type:  Journal Article; Twin Study    
Journal Detail:
Title:  Twin research and human genetics : the official journal of the International Society for Twin Studies     Volume:  13     ISSN:  1832-4274     ISO Abbreviation:  Twin Res Hum Genet     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-29     Completed Date:  2010-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101244624     Medline TA:  Twin Res Hum Genet     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  501-7     Citation Subset:  IM    
Istanbul Bakirkoy Maternity and Children Diseases Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey.
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MeSH Terms
Case-Control Studies
Chorion / pathology
Congenital Abnormalities / genetics*,  pathology,  therapy
Diseases in Twins / congenital*,  genetics*,  pathology,  therapy
Infant, Newborn
Pregnancy Outcome
Pregnancy, Multiple / genetics*
Premature Birth / etiology
Risk Factors
Twins, Dizygotic
Twins, Monozygotic

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