| Twin mothers, pregnancy hypertension and pre-eclampsia. | |
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MedLine Citation:
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PMID: 10426615 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To estimate the maternal genetic contribution to the hypertensive diseases of pregnancy. DESIGN: A cohort study of female twins with information on hypertensive diseases of pregnancy obtained by questionnaire screening, and verification of diagnosis from hospital or general practitioner records. SETTING: A volunteer twin registry in the UK with recruitment through the media without reference to pregnancies or disease status. POPULATION: Adult female, same-sex twin pairs who completed a pregnancy history questionnaire and consented to record inspection. MAIN OUTCOME MEASURE: Self-reported and hospital-validated diagnosis of non-proteinuric pregnancy hypertension and of pregnancy hypertension with proteinuria (pre-eclampsia). RESULTS: Self-reported pre-eclampsia had a heritability of 0.221 and non-proteinuric hypertension of 0. 198. However, none of the pairs who were self-reported as concordant for pre-eclampsia were confirmed from hospital records. Using hospital records, the heritability of pre-eclampsia was 0 and 0.375 for non-proteinuric hypertension. Using a model treating pre-eclampsia as a separate disease from non-proteinuric hypertension, and assuming that the next pair identified was both monozygotic and concordant for pre-eclampsia, the estimated heritability of pre-eclampsia remained 0 (95% CI 0-0.49). Using a threshold model in which non-proteinuric hypertension is treated as a mild form of pre-eclampsia, heritability is estimated at 0.247 (95% CI 0.23-0.454). CONCLUSION: Neither non-proteinuric hypertension nor pre-eclampsia are inherited in simple Mendelian fashion. The genetic contribution to multi-factorial inheritance is smaller than hitherto believed. |
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Authors:
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J G Thornton; A M Macdonald |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Twin Study |
Journal Detail:
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Title: British journal of obstetrics and gynaecology Volume: 106 ISSN: 0306-5456 ISO Abbreviation: Br J Obstet Gynaecol Publication Date: 1999 Jun |
Date Detail:
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Created Date: 1999-09-17 Completed Date: 1999-09-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7503752 Medline TA: Br J Obstet Gynaecol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 570-5 Citation Subset: AIM; IM |
Affiliation:
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Centre for Reproduction, Growth and Development, Leeds University and Leeds General Infirmary, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Cohort Studies Diseases in Twins / genetics* Female Humans Hypertension / genetics* Pre-Eclampsia / genetics* Pregnancy Pregnancy Complications, Cardiovascular Questionnaires |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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