| Twin analyses of fatigue. | |
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MedLine Citation:
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PMID: 17903114 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prolonged fatigue equal to or greater than 1 month duration and chronic fatigue equal to or greater than 6 months duration are both commonly seen in clinical practice, yet little is known about the etiology or epidemiology of either symptom. Chronic fatigue syndrome (CFS), while rarer, presents similar challenges in determining cause and epidemiology. Twin studies can be useful in elucidating genetic and environmental influences on fatigue and CFS. The goal of this article was to use biometrical structural equation twin modeling to examine genetic and environmental influences on fatigue, and to investigate whether these influences varied by gender. A total of 1042 monozygotic (MZ) twin pairs and 828 dizygotic (DZ) twin pairs who had completed the University of Washington Twin Registry survey were assessed for three fatigue-related variables: prolonged fatigue, chronic fatigue, and CFS. Structural equation twin modeling was used to determine the relative contributions of additive genetic effects, shared environmental effects, and individual-specific environmental effects to the 3 fatigue conditions. In women, tetrachoric correlations were similar for MZ and DZ pairs for prolonged and chronic fatigue, but not for CFS. In men, however, the correlations for prolonged and chronic fatigue were higher in MZ pairs than in DZ pairs. About half the variance for both prolonged and chronic fatigue in males was due to genetic effects, and half due to individual-specific environmental effects. For females, most variance was due to individual environmental effects. |
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Authors:
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Ellen Schur; Niloofar Afari; Jack Goldberg; Dedra Buchwald; Patrick F Sullivan |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Twin Study |
Journal Detail:
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Title: Twin research and human genetics : the official journal of the International Society for Twin Studies Volume: 10 ISSN: 1832-4274 ISO Abbreviation: Twin Res Hum Genet Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-10-01 Completed Date: 2008-03-14 Revised Date: 2013-06-06 |
Medline Journal Info:
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Nlm Unique ID: 101244624 Medline TA: Twin Res Hum Genet Country: Australia |
Other Details:
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Languages: eng Pagination: 729-33 Citation Subset: IM |
Affiliation:
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1 Department of Medicine, University of Washington School of Medicine, Seattle,Washington, USA. ellschur@washington.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Diseases in Twins / epidemiology*, genetics* Environment Fatigue / epidemiology*, genetics* Fatigue Syndrome, Chronic / epidemiology*, genetics* Female Humans Male Middle Aged Registries Twins, Dizygotic / genetics Twins, Monozygotic / genetics |
| Grant Support | |
ID/Acronym/Agency:
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5 U19 AI038429/AI/NIAID NIH HHS; K23 DK070826/DK/NIDDK NIH HHS; K23 DK070826-03/DK/NIDDK NIH HHS; R01 AR051524-03/AR/NIAMS NIH HHS; R01AR051524/AR/NIAMS NIH HHS; R55AR051524/AR/NIAMS NIH HHS; U19 AI038429-07/AI/NIAID NIH HHS |
| Comments/Corrections | |
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