| Twice vs three-times daily antibiotics in the treatment of pulmonary exacerbations of cystic fibrosis. | |
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MedLine Citation:
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PMID: 20920848 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Once daily dosing of aminoglycosides is widely used but is limited by the inconvenience of the slow infusion it requires and the associated three-times daily infusion of a beta-lactam. Twice daily tobramycin can be given as a slow IV bolus and may be more convenient. This study compares twice with three-times daily dosing of both tobramycin and ceftazidime. METHODS: This was a randomised, open-label, parallel group trial. CF patients presenting with an infective exacerbation were randomised to either twice or three-times daily ceftazidime and tobramycin. Markers of treatment efficacy and safety were measured in the two groups. The primary outcome measure was improvement in FEV1. RESULTS: 146 patients were randomised into the study. There was no significant difference in the two groups for improvement in FEV1% predicted (9.93% and 7.98% for twice daily and three-times daily respectively) and similar times to next exacerbation. There were no differences in the incidence of treatment failure, nephrotoxicity and ototoxicity. DISCUSSION: This study confirms that twice daily dosing of both tobramycin and ceftazidime is safe and effective and may be considered more convenient than current dosing schedules. |
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Authors:
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D Adeboyeku; A L Jones; M E Hodson |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society Volume: 10 ISSN: 1873-5010 ISO Abbreviation: J. Cyst. Fibros. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-18 Completed Date: 2011-05-03 Revised Date: 2011-10-17 |
Medline Journal Info:
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Nlm Unique ID: 101128966 Medline TA: J Cyst Fibros Country: Netherlands |
Other Details:
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Languages: eng Pagination: 25-30 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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North West London Hospitals NHS Trust, Central Middlesex Hospital, London, NW10 7NS, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Bacterial Agents / administration & dosage, adverse effects Ceftazidime* / administration & dosage, adverse effects Cystic Fibrosis / complications*, diagnosis Disease Progression Drug Administration Schedule Drug Monitoring Drug Therapy, Combination Ear Diseases / chemically induced Female Humans Injections, Intravenous Kidney Diseases / chemically induced Lung / microbiology, pathology Male Pseudomonas Infections / drug therapy*, etiology Pseudomonas aeruginosa / drug effects*, isolation & purification Respiratory Function Tests Tobramycin* / administration & dosage, adverse effects Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 32986-56-4/Tobramycin; 78439-06-2/Ceftazidime |
| Comments/Corrections | |
Comment In:
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J Cyst Fibros. 2011 Sep;10(5):383
[PMID:
21507733
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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