Document Detail

Twenty-two years' experience with childhood-onset SLE in a developing country: are outcomes similar to developed countries?
MedLine Citation:
PMID:  20930009     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The outcome of systemic lupus erythematosus (SLE) has dramatically improved since the introduction of corticosteroids; however, although many regimens of treatment have been supplemented, the mortality has not improved further.
OBJECTIVE: To describe the severity and outcome in patients diagnosed with SLE aged ≤18 years in a group of Thai children, compare gender and age differences, and our outcomes with those from developed countries.
METHODS: The authors retrospectively reviewed the files of patients aged ≤18 years diagnosed with SLE admitted to Songklanagarind University Hospital in southern Thailand, for the period 1985-2007. Patient survival rates were calculated.
RESULTS: There were 213 SLE patients, 41 males and 172 females, average age 11.6±2.6 years, with a median follow-up of 3.6 years. Outcomes were alive (109), lost to follow-up (22), referred (31) or deceased (51). Of the patients who were alive, 23 were not on any treatment, 59 were on prednisolone alone while 27 were on prednisolone plus some other immunosuppressive drug. Total survival rates were 88%, 76% and 64% at 2, 5 and 10 years, respectively. Males had significantly worse survival than females at 2 and 5 years (78% vs 91% and 58% vs 80%, respectively, p=0.018). There were no differences in mortality between age groups. The 5-year survival rates in the periods 1985-1993, 1994-2000 and 2001-2007 were not significantly different.
CONCLUSION: This retrospective study of patients with SLE in southern Thailand showed different outcomes compared to some studies and similar survival rates and treatment status to other studies, with one-fourth of surviving patients being free of medication.
Prayong Vachvanichsanong; Pornsak Dissaneewate; Edward McNeil
Related Documents :
11772589 - The effect of treatment and its related side effects in patients with severe ocular cic...
9413429 - Cytotoxic therapy in systemic lupus erythematosus. experience from a single center.
14987729 - Efficacy of intravenous immunoglobulin on the prevention of pneumonia in patients with ...
19577329 - Scalp necrosis in giant cell arteritis: case report and review of the relevance of this...
10910019 - Apheresis and selective adsorption plus immunoglobulin treatment in guillain-barré syn...
22149559 - Argon plasma coagulation and hyperbaric oxygen therapy in chronic radiation proctopathy...
22607789 - Increased septum wall thickness in patients undergoing aortic valve replacement predict...
24530199 - Comparison of early hemodynamic performance of 3 aortic valve bioprostheses.
7384969 - Parietal cell vagotomy.
Publication Detail:
Type:  Journal Article     Date:  2010-10-07
Journal Detail:
Title:  Archives of disease in childhood     Volume:  96     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-20     Completed Date:  2011-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  England    
Other Details:
Languages:  eng     Pagination:  44-9     Citation Subset:  AIM; IM    
Department of Pediatrics, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age Distribution
Developed Countries
Developing Countries*
Epidemiologic Methods
Glucocorticoids / therapeutic use
Lupus Erythematosus, Systemic / diagnosis,  drug therapy*,  mortality
Lupus Nephritis / mortality
Prednisolone / therapeutic use
Sex Distribution
Thailand / epidemiology
Treatment Outcome
Reg. No./Substance:
0/Glucocorticoids; 50-24-8/Prednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Monitoring asthma control in children with allergies by soft computing of lung function and exhaled ...
Next Document:  Bronchoalveolar lavage in children with cystic fibrosis: how many lobes should be sampled?