Document Detail


Twenty-three novel HLA-B alleles identified during intermediate-resolution testing.
MedLine Citation:
PMID:  16948646     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twenty-three novel human leukocyte antigen-B alleles are described: B*070204, *0738, *0742, *0821, *130202, *1312, *1575, *1598, *1599, *270507, *2728, *350104, *3558, *3811, *3931, *3932, *4045, *4107, *420501, *4812, *510106, *5520, and *5616. Thirteen of the variants are single-nucleotide substitutions from their most homologous allele, eight resulting in amino acid changes (B*0742, *1312, *1598, *1599, *3558, *3931, *4107, and *5616) and five with silent substitutions (B*070204, *130202, *270507, *350104, and *510106). Three alleles (B*0738, *4812, and *5520) differ by five nucleotide changes, altering four amino acids. The remaining seven alleles differ from their most similar alleles by two to three nucleotides, altering from one to two amino acids.
Authors:
A M Lazaro; K Cao; C Masaberg; N K Steiner; Y Xiao; B Tu; V Turner; P Nickerson; S Stoll; C Schall; R Valdez; J Ng; R J Hartzman; C K Hurley
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Tissue antigens     Volume:  68     ISSN:  0001-2815     ISO Abbreviation:  Tissue Antigens     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-04     Completed Date:  2006-11-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  245-8     Citation Subset:  IM    
Affiliation:
Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA.
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MeSH Terms
Descriptor/Qualifier:
Alleles
HLA-B Antigens / genetics*
Humans
Mutation
Chemical
Reg. No./Substance:
0/HLA-B Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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