| Twenty-three novel HLA-B alleles identified during intermediate-resolution testing. | |
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MedLine Citation:
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PMID: 16948646 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty-three novel human leukocyte antigen-B alleles are described: B*070204, *0738, *0742, *0821, *130202, *1312, *1575, *1598, *1599, *270507, *2728, *350104, *3558, *3811, *3931, *3932, *4045, *4107, *420501, *4812, *510106, *5520, and *5616. Thirteen of the variants are single-nucleotide substitutions from their most homologous allele, eight resulting in amino acid changes (B*0742, *1312, *1598, *1599, *3558, *3931, *4107, and *5616) and five with silent substitutions (B*070204, *130202, *270507, *350104, and *510106). Three alleles (B*0738, *4812, and *5520) differ by five nucleotide changes, altering four amino acids. The remaining seven alleles differ from their most similar alleles by two to three nucleotides, altering from one to two amino acids. |
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Authors:
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A M Lazaro; K Cao; C Masaberg; N K Steiner; Y Xiao; B Tu; V Turner; P Nickerson; S Stoll; C Schall; R Valdez; J Ng; R J Hartzman; C K Hurley |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Tissue antigens Volume: 68 ISSN: 0001-2815 ISO Abbreviation: Tissue Antigens Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-04 Completed Date: 2006-11-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0331072 Medline TA: Tissue Antigens Country: Denmark |
Other Details:
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Languages: eng Pagination: 245-8 Citation Subset: IM |
Affiliation:
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Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alleles HLA-B Antigens / genetics* Humans Mutation |
| Chemical | |
Reg. No./Substance:
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0/HLA-B Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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