Document Detail

Twenty-four-week follow-up examination of a leukocytapheresis therapy in rheumatoid arthritis.
MedLine Citation:
PMID:  16622719     Owner:  NLM     Status:  MEDLINE    
Several clinical trials have demonstrated that leukocytapheresis (LCAP) is a safe and effective therapy for patients with refractory rheumatoid arthritis (RA). However, most of those reports were limited to short-term clinical observation. We have treated 11 RA patients with LCAP and observed them for 24 weeks after the final administration. The 11 cases included 3 diabetes patients, 2 patients with interstitial pneumonia, 1 patient with diffuse panbronchiolitis, and 1 patient with old pulmonary tuberculosis. Alternative therapies for all of these patients were considered difficult. Once-a-week LCAP administration was added for 5 weeks to the previous therapeutic regime in all patients, and the treatment efficacy was prospectively qualified. At 4 weeks after the final LCAP therapy, 8 of the 11 patients (73%) had achieved an American College of Rheumatology (ACR) 20% response, and 3 of the 11 (27%) had achieved both ACR 50% and ACR 70% responses. Although the efficacy decreased after the observation periods, an ACR 20% response was maintained in 5 patients (45%) at 24 weeks. Although only a limited number of patients were examined in this study, the results suggested that LCAP therapy will be beneficial to RA patients, including patients who cannot be treated with tumor necrosis factor inhibitors or conventional disease-modifying antirheumatic drugs.
Yasumori Izumi; Masahiro Tominaga; Nozomi Iwanaga; Mingguo Huang; Fumiko Tanaka; Kouichiro Aratake; Kazuhiko Arima; Mami Tamai; Makoto Kamachi; Hideki Nakamura; Hiroaki Ida; Tomoki Origuchi; Atsushi Kawakami; Katsumi Eguchi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Modern rheumatology / the Japan Rheumatism Association     Volume:  16     ISSN:  1439-7595     ISO Abbreviation:  Mod Rheumatol     Publication Date:  2006  
Date Detail:
Created Date:  2006-04-19     Completed Date:  2006-08-29     Revised Date:  2007-08-01    
Medline Journal Info:
Nlm Unique ID:  100959226     Medline TA:  Mod Rheumatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  20-3     Citation Subset:  IM    
First Department of Internal Medicine, Graduate School of Biochemical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
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MeSH Terms
Arthritis, Rheumatoid / therapy*
Follow-Up Studies
Middle Aged
Statistics, Nonparametric
Time Factors
Treatment Outcome

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