Document Detail

Twenty-four-hour urinary thiamine as a biomarker for the assessment of thiamine intake.
MedLine Citation:
PMID:  17565356     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate 24-h urinary thiamine as a potential biomarker for thiamine intake for use in validation studies to assess the validity of dietary intake data collected by self-reporting dietary methods. SUBJECTS: Seven male and six female healthy participants living for 30 days in a metabolic suite under strictly controlled conditions consuming their usual diet as assessed beforehand from four consecutive 7-day food diaries kept at home. During the 30-day study, all 24-h urine specimens were collected, validated for their completeness and analysed for thiamine. RESULTS: Thirty-day mean (+/-s.d.) calculated thiamine intake was 2.22+/-0.55 mg/day. Thirty-day mean (+/-s.d.) urinary excretion of thiamine was 526.5+/-193.0 microg/day (24.7+/-8.10% of intake). There was a highly significant correlation between individuals' 30-day means of thiamine intake and their mean excretion level (r=0.720; P=0.006), where 1 mg of thiamine intake predicted 268.2 microg of thiamine in urine. The correlations between intake and excretion remained significant when measurement from a single 24-h urine collection was used (r=0.56). CONCLUSION: Twenty-four-hour urinary thiamine can be used as a concentration biomarker for thiamine intake in dietary validation studies.
N Tasevska; S A Runswick; A McTaggart; S A Bingham
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-13
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  62     ISSN:  0954-3007     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-03     Completed Date:  2009-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  1139-47     Citation Subset:  IM    
MRC Dunn Human Nutrition Unit, University of Cambridge, Cambridge, UK.
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MeSH Terms
Biological Markers / urine
Diet Records
Food Analysis
Middle Aged
Nutrition Assessment*
Thiamine / administration & dosage,  urine*
Young Adult
Grant Support
//Medical Research Council
Reg. No./Substance:
0/Biological Markers; 59-43-8/Thiamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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