| Twenty-four-hour ocular hypotensive effects of 0.0015% tafluprost and 0.005% latanoprost in healthy subjects. | |
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MedLine Citation:
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PMID: 20700794 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To compare the intraocular pressure (IOP) reduction over 24 h achieved with tafluprost (0.0015%) with that achieved with latanoprost (0.005%). METHODS: Twenty-seven healthy volunteers were studied. After a 24-h IOP baseline measurement was taken, one ophthalmic solution was applied to the right eye daily for 7 days. The drug was then withdrawn for 2 weeks. The other agent was then applied to the left eye in the same manner. IOP was measured every 3 h for 24 h on the seventh day of treatment. RESULTS: The 24-h IOP after 7 days' treatment with latanoprost decreased from 11.5 mmHg at baseline to 9.7 mmHg (-1.8 mmHg) and that with tafluprost from 11.8 to 9.8 mmHg (-1.9 mmHg). Tafluprost was statistically more effective after 24 h (P = 0.007; paired t test). The number of subjects with a 24-h mean IOP reduction of <10% was 8/27 (29.6%) with latanoprost versus 4/27 (14.8%) with tafluprost. The incidence of conjunctival hyperemia with latanoprost was 4/27 (14.8%) and that with tafluprost was 8/27 (29.6%). CONCLUSION: The overall efficacies of the two agents were not different, but tafluprost was associated with a greater reduction in IOP at 24 h after administration. Tafluprost showed a higher rate of conjunctival hyperemia. |
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Authors:
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Hideki Mochizuki; Hideki Itakura; Tomoko Yokoyama; Michiya Takamatsu; Yoshiaki Kiuchi |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2010-08-11 |
Journal Detail:
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Title: Japanese journal of ophthalmology Volume: 54 ISSN: 1613-2246 ISO Abbreviation: Jpn. J. Ophthalmol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-08-11 Completed Date: 2010-10-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0044652 Medline TA: Jpn J Ophthalmol Country: Japan |
Other Details:
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Languages: eng Pagination: 286-90 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology and Visual Science, Graduate School of Biomedical Science, Hiroshima University, Minami-ku, Hiroshima, Japan. mochizuki-h@hiroshima-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adult Antihypertensive Agents / administration & dosage*, adverse effects Circadian Rhythm / drug effects* Cross-Over Studies Female Humans Intraocular Pressure / drug effects* Male Ophthalmic Solutions / administration & dosage*, adverse effects Prospective Studies Prostaglandins F / administration & dosage*, adverse effects Prostaglandins F, Synthetic / administration & dosage*, adverse effects Tonometry, Ocular Visual Acuity Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Ophthalmic Solutions; 0/Prostaglandins F; 0/Prostaglandins F, Synthetic; 0/tafluprost; 130209-82-4/latanoprost |
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