| Twenty-four hour changes in active and inactive renin after various oral doses of the converting enzyme inhibitor ramipril (HOE498) in normal man. | |
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MedLine Citation:
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PMID: 3023553 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Different oral doses (5, 20, 50 mg) of the new orally active nonsulfhydryl-converting enzyme inhibitor, ramipril (HOE498), were given to 12 normotensive healthy males, and the pattern of changes in plasma active and inactive renin concentration was evaluated. Active and inactive renin increased after ramipril, and the magnitude of the response was clearly dose related. Active renin rose markedly by 4 hours and tended to decrease thereafter, although remaining higher than basal at 24 hours. In contrast, inactive renin rose more slowly, and the increase was sustained throughout the 24-hour period. The pattern of these changes is consistent with the hypothesis that circulating inactive renin is a biosynthetic precursor of the active form. |
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Authors:
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L S Malatino; P Manhem; S G Ball; B J Leckie; J J Morton; G D Murray; J I Robertson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of clinical hypertension Volume: 2 ISSN: 0748-450X ISO Abbreviation: J Clin Hypertens Publication Date: 1986 Sep |
Date Detail:
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Created Date: 1987-01-08 Completed Date: 1987-01-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8510461 Medline TA: J Clin Hypertens Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 231-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Angiotensin I / blood Angiotensin II / blood Angiotensin-Converting Enzyme Inhibitors* Bicyclo Compounds / pharmacology* Blood Pressure / drug effects Bridged Compounds / pharmacology* Dose-Response Relationship, Drug Humans Male Ramipril Renin / blood* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Bicyclo Compounds; 0/Bridged Compounds; 11128-99-7/Angiotensin II; 87333-19-5/Ramipril; 9041-90-1/Angiotensin I; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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