Document Detail

Twenty-four-hour ambulatory heart rate and organ damage in primary hypertension.
MedLine Citation:
PMID:  20070252     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The relationship between basal heart rate (HR) and the occurrence of myocardial ischemia, sudden death, cardiovascular mortality have been described. Therefore, further studies are warranted to evaluate the behaviour of heart rate in different scenarios. We sought to determine whether ambulatory heart rate is associated with the presence of target organ damage (TOD) in hypertensive patients. PATIENTS AND METHODS: Crossectional study of essential hypertensive patients in whom a twenty-four hour ambulatory blood pressure monitoring (ABPM) was performed. The relationship between TOD and 24 hour ambulatory heart rate (HR) was analyzed. RESULTS: Five hundred and sixty-six patients with arterial hypertension were included (55.8% male, mean age 59.9 +/- 14.2 years). 15% were smokers, 62.2% had dyslipidemia, 18.4% diabetes mellitus. Heart rate values were higher during activity as compared to the resting period (72.8 vs 63.3 bpm, p < 0.001). Heart rate, in both periods, was not associated with the presence of TOD. Nevertheless, the patients with nocturnal HR > or = 65 bpm have high risk and a high prevalence of TOD. This relationship was also present in multivariate analysis (HR 2.41; CI 95% 1.41-4.11; p=0.001). CONCLUSION: An elevated nocturnal HR, > or = 65 bpm, obtained with ABPM registry, is associated with the presence of TOD in hypertensive patients. ABPM is a powerful tool for hypertensive patients not only to monitor BP control but also to obtain information on HR which may provide additional information about current and future cardiovascular risk.
Lorenzo Fácila; Vicente Pallarés; Ana Peset; Manuel Pérez; Vicente Gil; Vicente Montagud; Vicente Bellido; Vicente Bertomeu-Gonzalez; Josep Redón
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Blood pressure     Volume:  19     ISSN:  1651-1999     ISO Abbreviation:  Blood Press.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-06     Completed Date:  2010-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  England    
Other Details:
Languages:  eng     Pagination:  104-9     Citation Subset:  IM    
Consorcio Hospitalario Provincial de Castellón, España.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antihypertensive Agents / therapeutic use
Blood Pressure
Blood Pressure Monitoring, Ambulatory
Brain Ischemia / complications,  drug therapy
Cardiovascular Diseases / complications,  drug therapy
Cross-Sectional Studies
Heart Rate / physiology*
Hypertension / complications*,  drug therapy,  physiopathology
Middle Aged
Myocardial Ischemia / complications,  drug therapy
Risk Factors
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of cigarette smoking on blood pressure stratified by BMI in Mongolian population, China.
Next Document:  Functional interaction between Smad3 and S100A4 (metastatin-1) for TGF-beta-mediated cancer cell inv...