Document Detail

Twenty-four-hour ambulatory esophageal pH monitoring in the diagnosis of acid reflux-related chronic cough.
MedLine Citation:
PMID:  9076302     Owner:  NLM     Status:  MEDLINE    
To define the role of ambulatory pH monitoring in evaluating chronic cough, we studied esophageal pH values of patients referred to a gastroenterology laboratory. Chronic cough was evaluated in 31 patients, who were grouped based on response to treatments; 11 patients (35.5%) had gastroesophageal reflux (GER)-related cough, 11 (35.5%) had pulmonary/otorhinolaryngologic-related cough (1 bronchitis, 6 asthma, 2 postnasal drip, 1 pneumonia), and 9 patients (29%) had cough of unknown etiology. Esophageal pH values of groups were compared. Excessive acid reflux distally (upright and supine) and proximally (upright) and cough symptom frequency related to acid reflux were significantly higher in patients with GER. Esophageal pH monitoring had good sensitivity (91%), specificity (82%), and positive (83%) and negative (90%) predictive values in identifying GER-related cough. In summary, ambulatory pH monitoring is an excellent test for identifying patients with GER-related cough.
M F Vaezi; J E Richter
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  90     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-04-17     Completed Date:  1997-04-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  305-11     Citation Subset:  AIM; IM    
Division of Gastroenterology, University of Alabama at Birmingham, USA.
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MeSH Terms
Analysis of Variance
Asthma / diagnosis
Bronchitis / diagnosis
Chronic Disease
Cough / etiology*,  physiopathology
Esophagogastric Junction / physiopathology
Esophagus / physiopathology*
Gastric Acid
Gastric Acidity Determination
Gastroesophageal Reflux / complications,  diagnosis*,  physiopathology
Hydrogen-Ion Concentration
Middle Aged
Monitoring, Ambulatory*
Nose Diseases / diagnosis
Pneumonia / diagnosis
Predictive Value of Tests
Sensitivity and Specificity
Supine Position

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