| Twenty-four-hour ambulatory blood pressure and vasoactive hormones in valvular aortic disease. | |
| | |
MedLine Citation:
|
PMID: 8879602 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of this study was to assess the blood pressure profile and vasoactive hormones in valvular aortic disease. Thirteen aortic stenosis and/or aortic regurgitation patients were matched with 13 control subjects. Ambulatory blood pressure monitoring was performed for 24 h. Arterial and venous plasma concentrations of renin, angiotensin II, aldosterone, arginine vasopressin, atrial natriuretic peptide, immunoreactive endothelin and cyclic-GMP were measured. The mean 24-h blood pressure was higher in the patient group (94.9 mmHg) compared with control subjects (88.2 mmHg) (p < 0.0001), despite no differences in daytime blood pressures. The nocturnal blood pressure fall was attenuated in the patients (systolic/diastolic blood pressure -8.5/-3.5; -20.3/-14.3 mmHg (p < 0.001/p < 0.01)); in heart rate too the nightly fall was blunted in the patients (-4.8/ -13.4/min (p < 0.0013)). PRA, Ang II, AVP, ANP, ir-ET and cGMP were significantly increased in the patients compared to the controls. Nightly systolic blood pressure fall was inversely related to arterial (r = -0.75, p < 0.003) and venous (r = -0.65, p < 0.04) plasma renin activity and arterial aldosterone (r = -0.64, p < 0.05) in valvular aortic disease patients. In conclusion, valvular aortic disease patients have attenuated falls in blood pressure and heart rate during the night. Increased activity in the renin aldosterone system may be involved in this abnormal blood pressure regulation. |
| | |
Authors:
|
L W Jensen; J P Bagger; E B Pedersen |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Blood pressure Volume: 5 ISSN: 0803-7051 ISO Abbreviation: Blood Press. Publication Date: 1996 Sep |
Date Detail:
|
Created Date: 1997-01-17 Completed Date: 1997-01-17 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9301454 Medline TA: Blood Press Country: NORWAY |
Other Details:
|
Languages: eng Pagination: 292-9 Citation Subset: IM |
Affiliation:
|
Research Laboratory for Nephrology and Hypertension, Skejby Hospital, Aarhus, Denmark. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aldosterone / blood Angiotensin II / blood Aortic Valve Insufficiency / blood*, physiopathology* Aortic Valve Stenosis / blood*, physiopathology* Arginine Vasopressin / blood Atrial Natriuretic Factor / blood Blood Pressure / physiology* Blood Pressure Monitoring, Ambulatory Circadian Rhythm Cyclic GMP / blood Endothelins / blood Female Heart Rate / physiology Hormones / blood* Humans Male Middle Aged Renin / blood |
| Chemical | |
Reg. No./Substance:
|
0/Endothelins; 0/Hormones; 11128-99-7/Angiotensin II; 113-79-1/Arginine Vasopressin; 52-39-1/Aldosterone; 7665-99-8/Cyclic GMP; 85637-73-6/Atrial Natriuretic Factor; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The efficacy of felodipine ER on regression of left ventricular hypertrophy in patients with primary...
Next Document: The Swedish Trial in old patients with hypertension-2 (STOP-hypertension-2): a progress report.