Document Detail

Twenty-four-hour ambulatory blood pressure monitoring in the follow-up of the univentricular heart after Fontan repair.
MedLine Citation:
PMID:  23147533     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: In a univentricular heart corrected with a Fontan repair (UVH-F), a single pumping chamber is responsible for both systemic and pulmonary circulations. To evaluate the influence of afterload on cardiac output (CO) of UVH-F, this study aimed at (a) evaluating 24-h ambulatory blood pressure monitoring (ABPM) data of a group of UVH-F patients compared with a control group of healthy individuals (C) and (b) examining possible correlations between afterload measure [elastance (Ea)] derived from ABPM with (i) CO as calculated from pulse pressure and heart rate (ii) cardiac index (CI) as calculated from pulse pressure, heart rate and body surface.
METHODS: Ten UHV-F patients (four males, six females, mean age at study: 12.6±0.6 years, and mean time from surgery: 7.2±1.7 years) were enrolled. A 24-h ABPM was performed.
RESULTS: (UVH-F vs. C) Systolic blood pressure (101±3 vs. 112±3 mmHg, P<0.0001); diastolic blood pressure (59±3 vs. 72±3 mmHg, P<0.0001); mean arterial ressure (73±3 vs. 85±3 mmHg, P<0.0001); heart rate (68±6 vs. 87±5 beats/min, P<0.0001); CO (2.85±0.4 vs. 3.48±0.2 l/min, P<0.0001); and CI (2.51±0.2 vs. 2.92±0.1 l/min/m, P<0.0001) were determined. In UVH-F, CO was related inversely to Ea (r=-0.81, P<0.004). CI and Ea were also related (r=±0.82, P<0.003). CO and time since surgery were inversely related (r=-0.98, P<0.0001).
CONCLUSION: In UVH-F 24 h, single ventricle afterload and CO are inversely related. When correcting CO for body surface to obtain CI, the graphic representation of their reciprocal relationship appears to be more explanatory for UVH-F haemodynamics.
Pier P Bassareo; Andrea R Marras; Giuseppe Mercuro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood pressure monitoring     Volume:  17     ISSN:  1473-5725     ISO Abbreviation:  Blood Press Monit     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606438     Medline TA:  Blood Press Monit     Country:  England    
Other Details:
Languages:  eng     Pagination:  243-7     Citation Subset:  IM    
Department of Medical Sciences 'M.Aresu', University of Cagliari, Cagliari, Italy.
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