| Twenty-five years of translational medicine in antiretroviral therapy: promises to keep. | |
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MedLine Citation:
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PMID: 20610849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The year 2010 marks the 25th anniversary of modern antiretroviral drug discovery and development. In the early 1980s, AIDS was almost always a lethal disease with an appalling clinical course characterized by severe opportunistic infections and unusual forms of cancer. Since that time, starting with zidovudine (AZT) and related 2',3'-dideoxynucleosides, the causative retrovirus, now called HIV-1, went from being an untreatable infectious agent to being the target of highly active antiretroviral therapy (HAART). This degree of progress refuted early prophesies of therapeutic futility and represents a striking example of translational medicine. Here I review foundational discoveries and events in HIV-1/AIDS research and explore lessons for future translational medicine efforts. |
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Authors:
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Samuel Broder |
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Publication Detail:
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Type: Historical Article; Journal Article |
Journal Detail:
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Title: Science translational medicine Volume: 2 ISSN: 1946-6242 ISO Abbreviation: Sci Transl Med Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-12-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101505086 Medline TA: Sci Transl Med Country: United States |
Other Details:
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Languages: eng Pagination: 39ps33 Citation Subset: IM |
Affiliation:
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Celera Corporation, 1901 Research Boulevard, Rockville, MD 20850-3180, USA. broderse@celera.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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drug therapy,
epidemiology,
history*,
psychology Antiretroviral Therapy, Highly Active / history* Cooperative Behavior Fear History, 20th Century History, 21st Century Humans Translational Research / history*, trends* Zidovudine / therapeutic use |
| Chemical | |
Reg. No./Substance:
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30516-87-1/Zidovudine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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