| Twenty-five years of infant dialysis: a single center experience. | |
| | |
MedLine Citation:
|
PMID: 19324367 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To perform a retrospective analysis of the long-term outcome of infants with end-stage kidney disease (ESKD) treated at our center during the past 25 years. STUDY DESIGN: The total cohort (n = 52) was divided into era 1 (1983-1995; n = 23) and era 2 (1996-2008; n = 29). Dialysis morbidity, transplantation, and long-term survival rates were assessed and compared between the 2 eras. RESULTS: Average age at initiation of dialysis was 4.4 +/- 5.3 months (range, 0.5-18 months), with 96% begun on peritoneal dialysis. The predominant diagnoses were dysplasia/obstructive uropathy and autosomal recessive polycystic kidney disease. The overall survival rate is 46%, with current age of survivors ranging from 1.5 to 25 years. Mortality rates in the 2 eras were not significantly different. The predominant mortality occurred within the first year. Twenty-four patients received an initial renal transplant at 2.6 +/- 1.7 years of age. Six patients (25%) required a second renal allograft. Increased risk for mortality included African-American ethnicity, oligoanuria, autosomal recessive polycystic kidney disease, and co-morbid diagnoses. CONCLUSIONS: Long-term survival is possible in infants with ESKD, although mortality and morbidity remain high. Technical innovations are needed to accommodate smaller infants undergoing dialysis. Early initiation of dialysis treatment is preferable because prognostic indicators remain poorly defined. |
| | |
Authors:
|
Rana Hijazi; Carolyn L Abitbol; Jayanthi Chandar; Wacharee Seeherunvong; Michael Freundlich; Gastón Zilleruelo |
Related Documents
:
|
21721107 - Neutropenia in infants with hemolytic disease of the newborn. 16585307 - Treated hypotension is associated with neonatal morbidity and hearing loss in extremely... 19124387 - Pre-eclampsia: the pivotal role of the placenta in its pathophysiology and markers for ... 10486487 - Morbidity assessment index for newborns: a composite tool for measuring newborn health. 3224777 - Development of abr parameters in a preterm and a term born population. 23158057 - Adolescent mothers and older mothers: who is at higher risk for adverse birth outcomes? |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-03-25 |
Journal Detail:
|
Title: The Journal of pediatrics Volume: 155 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2009 Jul |
Date Detail:
|
Created Date: 2009-06-29 Completed Date: 2009-07-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
|
Languages: eng Pagination: 111-7 Citation Subset: AIM; IM |
Affiliation:
|
Division of Pediatric Nephrology, University of Miami/Holtz Children's Hospital, Miami, FL, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
African Continental Ancestry Group Anuria / epidemiology Child, Preschool Cohort Studies Comorbidity Developmental Disabilities / epidemiology Female Florida / epidemiology Gastrostomy Humans Infant Infant, Newborn Kidney Failure, Chronic / mortality*, therapy* Liver Transplantation / statistics & numerical data* Male Oliguria / epidemiology Peritonitis / epidemiology Polycystic Kidney Diseases / epidemiology Renal Dialysis* Retrospective Studies Survival Analysis Ureteral Obstruction / epidemiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The role of patent ductus arteriosus ligation in bronchopulmonary dysplasia: reexamining a randomize...
Next Document: Activity-promoting video games and increased energy expenditure.