| Twenty-five years of epidemiological recording on myeloid malignancies: data from the specialized registry of hematologic malignancies of Cote d'Or (Burgundy, France). | |
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MedLine Citation:
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PMID: 20971817 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Epidemiological data on myeloid malignancies are very rare in the literature due to a lack of registration by cancer registries until 2000. The Registry of Hematologic Malignancies of the Côte d'Or Department in France has, however, steadfastly registered data on cases occurring in the Department since 1980, resulting, to date, in a database of over 5,000 cases classified according to the ICD-O-3 classification, following the most recent World Health Organization classification criteria. DESIGN AND METHODS: Twenty-five years of data on myeloid malignancies, including acute myeloid leukemia, myeloproliferative neoplasms, myelodysplastic syndromes and myelodysplastic/myeloproliferative syndromes were analyzed. World population standardized incidence rates were calculated as were as observed and relative survival. RESULTS: Incidence rates per 100,000 inhabitants/year were 2.5 for acute myeloid leukemia, 1.3 for myelodysplastic syndromes, 3.2 for myeloproliferative neoplasms and 0.6 for myelodysplastic/myeloproliferative syndromes. It was found that the incidence rate of myelodysplastic syndromes increased significantly over the period. The median overall survival is 8.9 months for patients with acute myeloid leukemia, 33.8 months for patients with myelodysplastic syndromes, 91.7 months for those with myeloproliferative neoplasms and 26.6 months for patients with myelodysplastic/myeloproliferative syndromes. Observed and relative 20-year survival rates are, respectively, 12% and 13% in acute myeloid leukemia, 2% and 6% in myelodysplastic syndromes and 20% and 34% in myeloproliferative neoplasms. CONCLUSIONS: These population-based data on myeloid malignancies are the first data collected over such a long period and provide interesting information for clinicians and public health authorities, particularly given the paucity of other long-term, population-based data from cancer registries. |
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Authors:
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Marc Maynadié; François Girodon; Ines Manivet-Janoray; Morgane Mounier; Francine Mugneret; François Bailly; Bernardine Favre; Denis Caillot; Tony Petrella; Michel Flesch; Paule-Marie Carli |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-22 |
Journal Detail:
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Title: Haematologica Volume: 96 ISSN: 1592-8721 ISO Abbreviation: Haematologica Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-03 Completed Date: 2011-05-26 Revised Date: 2011-07-20 |
Medline Journal Info:
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Nlm Unique ID: 0417435 Medline TA: Haematologica Country: Italy |
Other Details:
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Languages: eng Pagination: 55-61 Citation Subset: IM |
Affiliation:
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Registre des Hémopathies Malignes de Côte d'Or, EA 4184, Faculté de Médecine, Dijon Cedex, France. Marc.maynadie@u-bourgogne.fr |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Female France / epidemiology Humans Incidence Leukemia, Myeloid, Acute / epidemiology* Male Middle Aged Myelodysplastic Syndromes / epidemiology* Myeloproliferative Disorders / epidemiology* Prognosis Records as Topic Registries Sex Factors Survival Rate Time Factors |
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