Document Detail

Twelve-year-old girl with primary biliary cirrhosis.
MedLine Citation:
PMID:  23243543     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Primary biliary cirrhosis (PBC) is a slowly progressive cholestatic liver disease of autoimmune etiology. The initial presentation of PBC is varies from asymptomatic, abnormal liver biochemical tests to overt cirrhosis. Unlike other autoimmune liver diseases, PBC has rarely been reported in childhood. We report a case of primary biliary cirrhosis in a 12-year-old girl. In addition to characteristic histology features, strongly positive antimitochondrial antibodies, increased liver enzyme levels, increased serum quantitative immunoglobulin M levels, and cholestasis were discovered. She had been treated with ursodeoxycholic acid. In the world literature, we found only few pediatric patients of primary biliary cirrhosis. Aetiology, pathogenesis, the long-term natural history, and prognosis remain obscure. Due to increased awareness of early-onset PBC, rather than typical older ones, further pediatric cases may be discovered.
Ivana Kitic; Aleksandra Boskovic; Ivica Stankovic; Dragan Prokic
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Publication Detail:
Type:  Journal Article     Date:  2012-11-27
Journal Detail:
Title:  Case reports in pediatrics     Volume:  2012     ISSN:  2090-6811     ISO Abbreviation:  Case Rep Pediatr     Publication Date:  2012  
Date Detail:
Created Date:  2012-12-17     Completed Date:  2012-12-18     Revised Date:  2013-03-05    
Medline Journal Info:
Nlm Unique ID:  101581030     Medline TA:  Case Rep Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  937150     Citation Subset:  -    
Department of Gastroenterology and Hepatology, Mother and Child Health Care Institute, Radoja Dakica 6-8, Belgrade, 11070 New Belgrade, Serbia.
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