| Twelve-year-old girl with primary biliary cirrhosis. | |
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MedLine Citation:
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PMID: 23243543 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Primary biliary cirrhosis (PBC) is a slowly progressive cholestatic liver disease of autoimmune etiology. The initial presentation of PBC is varies from asymptomatic, abnormal liver biochemical tests to overt cirrhosis. Unlike other autoimmune liver diseases, PBC has rarely been reported in childhood. We report a case of primary biliary cirrhosis in a 12-year-old girl. In addition to characteristic histology features, strongly positive antimitochondrial antibodies, increased liver enzyme levels, increased serum quantitative immunoglobulin M levels, and cholestasis were discovered. She had been treated with ursodeoxycholic acid. In the world literature, we found only few pediatric patients of primary biliary cirrhosis. Aetiology, pathogenesis, the long-term natural history, and prognosis remain obscure. Due to increased awareness of early-onset PBC, rather than typical older ones, further pediatric cases may be discovered. |
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Authors:
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Ivana Kitic; Aleksandra Boskovic; Ivica Stankovic; Dragan Prokic |
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Publication Detail:
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Type: Journal Article Date: 2012-11-27 |
Journal Detail:
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Title: Case reports in pediatrics Volume: 2012 ISSN: 2090-6811 ISO Abbreviation: Case Rep Pediatr Publication Date: 2012 |
Date Detail:
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Created Date: 2012-12-17 Completed Date: 2012-12-18 Revised Date: 2013-03-05 |
Medline Journal Info:
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Nlm Unique ID: 101581030 Medline TA: Case Rep Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 937150 Citation Subset: - |
Affiliation:
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Department of Gastroenterology and Hepatology, Mother and Child Health Care Institute, Radoja Dakica 6-8, Belgrade, 11070 New Belgrade, Serbia. |
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