Document Detail


Twelve weeks of endurance training increases FFA mobilization and reesterification in postmenopausal women.
MedLine Citation:
PMID:  20651217     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined the effects of exercise intensity and training on rates of lipolysis, plasma free fatty acid (FFA) appearance (R(a)), disappearance (R(d)), reesterification (R(s)), and oxidation (R(oxP)) in postmenopausal (PM) women. Ten sedentary but healthy women (55 ± 0.6 yr) completed 12 wk of supervised endurance exercise training on a cycle ergometer [5 days/wk, 1 h/day, 65% peak oxygen consumption (Vo(2peak))]. Flux rates were determined by continuous infusion of [1-(13)C]palmitate and [1,1,2,3,3-(2)H(5)]glycerol during 90 min of rest and 60 min of cycle ergometer exercise during one pretraining exercise trial [65% Vo(2peak) (PRE)] and two posttraining exercise trials [at power outputs that elicited 65% pretraining Vo(2peak) (absolute training; ABT) and 65% posttraining Vo(2peak) (relative training; RLT)]. Initial body weights (68.2 ± 4.5 kg) were maintained over the course of study. Training increased Vo(2peak) by 16.3 ± 3.9% (P < 0.05) (Zarins ZA, Wallis GA, Faghihnia N, Johnson ML, Fattor JA, Horning MA and Brooks GA. Metabolism 58: 9: 1338-1346, 2009). Glycerol R(a) and R(d) were elevated in the RLT trial (P < 0.05), but not the ABT trial after training. Rates of plasma FFA R(a), R(d), and R(oxP) were elevated during the ABT compared with PRE trial (P < 0.05). FFA R(s) accounted for most (50-70%) of R(d) during exercise; training reduced FFA R(s) during ABT, but not RLT compared with PRE. We conclude that, despite the large age-related decrease in metabolic scope in PM women, endurance training increases the capacities for FFA mobilization and oxidation during exercises of a given power output. However, after menopause, total lipid oxidation capacity remains low, with reesterification accounting for most of FFA R(d).
Authors:
M L Johnson; Z Zarins; J A Fattor; M A Horning; L Messonnier; S L Lehman; G A Brooks
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2010-07-22
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  109     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-03-25     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1573-81     Citation Subset:  IM    
Affiliation:
Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, Berkeley, CA 94720-3140, USA. gbrooks@berkeley.edu.
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MeSH Terms
Descriptor/Qualifier:
Aging / metabolism*
Bicycling
Body Weight
Carbon Isotopes
Energy Metabolism*
Esterification
Fatty Acids, Nonesterified / administration & dosage,  blood,  metabolism*
Female
Glycerol / administration & dosage,  metabolism
Humans
Infusions, Intravenous
Kinetics
Lipolysis*
Middle Aged
Oxidation-Reduction
Oxygen Consumption
Palmitic Acid / administration & dosage,  metabolism
Physical Endurance*
Postmenopause*
Grant Support
ID/Acronym/Agency:
R01 AR042906/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Carbon Isotopes; 0/Fatty Acids, Nonesterified; 56-81-5/Glycerol; 57-10-3/Palmitic Acid
Comments/Corrections
Comment In:
J Appl Physiol (1985). 2010 Dec;109(6):1569-70   [PMID:  20884835 ]

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