Document Detail

Twelve-month neurofunctional assessment and cognitive performance at 36 months of age in extremely low birth weight infants.
MedLine Citation:
PMID:  17974738     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective of this study was to investigate whether an early neurofunctional assessment (at 12 months' corrected age) is predictive of cognitive outcome at 36 months of age in extremely low birth weight infants. METHODS: We conducted an observational longitudinal study. Neurodevelopmental outcome by means of a neurofunctional assessment was evaluated at 12 months' corrected age and 36 months' chronological age in 141 extremely low birth weight children. Cognitive outcome was assessed with use of the Griffiths Mental Developmental Scale. RESULTS: A significant association was found between the 12-month neurofunctional status and cognitive performance at 36 months. A higher general quotient on the Griffiths Mental Developmental Scale at 36 months was observed in infants who exhibited normal (score: < or = 1) neurodevelopment compared with children who exhibited minor (score: 2) and major (score: > or = 3) dysfunctions at the 12-month neurofunctional evaluation (99 +/- 6.8 vs 85.3 +/- 16.3 vs 57.3 +/- 22.0). A score of > or = 2 at the 12-month neurofunctional assessment, abnormal brain MRI results at term, and chronic lung disease remained predictive of cognitive delay at 36 months of age and also after adjustment for confounders. CONCLUSIONS: The 12-month neurofunctional evaluation may be an additional useful clinical tool in predicting later cognitive outcome in extremely low birth weight children.
Maria Lorella Giannì; Odoardo Picciolini; Chiara Vegni; Laura Gardon; Monica Fumagalli; Fabio Mosca
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pediatrics     Volume:  120     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-02     Completed Date:  2007-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1012-9     Citation Subset:  AIM; IM    
Neonatal Intensive Care Unit, Institute of Pediatrics and Neonatology, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena University Medical School, Milan, Italy.
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MeSH Terms
Child Development / physiology*
Child, Preschool
Cognition / physiology*
Follow-Up Studies
Infant, Extremely Low Birth Weight / physiology*,  psychology*
Infant, Newborn
Neurologic Examination / methods*

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