Document Detail

Twelve weeks of treadmill exercise does not alter age-dependent chronic kidney disease in the Fisher 344 male rat.
MedLine Citation:
PMID:  21969451     Owner:  NLM     Status:  MEDLINE    
The ageing kidney exhibits slowly developing chronic kidney disease (CKD) and is associated with nitric oxide (NO) deficiency and increased oxidative stress. The impact of exercise on the ageing kidney is not well understood. Here, we determined whether 12 weeks of treadmill exercise can influence age-dependent CKD in old (22-24 months) Fisher 344 (F344) male rats by comparing sedentary (SED) and exercise (EX) trained rats; young (3 months) rats were also studied. In addition to renal structure and function, we assessed protein levels of various isoforms of the NO synthases (NOS) and superoxide dismutase (SOD) enzymes as well as markers of oxidative stress, in kidney cortex and medulla. Renal function as determined by plasma creatinine, proteinuria, and glomerular structural injury worsened with age and was unaffected by exercise. Ageing also increased the protein abundance of neuronal NOSβ and p22phox while decreasing extracellular (EC) and copper/zinc (CuZn) SOD, in kidney cortex and medulla. H(2)O(2) content and nitrotyrosine abundance also increased in the kidney with age. None of these age-related changes were altered with exercise. However, exercise did increase renal cortical endothelial (e)NOS and EC SOD in young rats. Data indicate that exercise-induced increases in eNOS and EC SOD seen in young rats are lost with age. We conclude that chronic exercise is ineffective in reversing age-dependent CKD in the male F344 rat.
Natasha C Moningka; Amy L Sindler; Judy M Muller-Delp; Chris Baylis
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-10-03
Journal Detail:
Title:  The Journal of physiology     Volume:  589     ISSN:  1469-7793     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-16     Completed Date:  2012-05-31     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  6129-38     Citation Subset:  IM    
Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL 32610, USA.
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MeSH Terms
Aging / physiology*
Aorta / metabolism
Chronic Disease
Hydrogen Peroxide / metabolism
Kidney / metabolism,  pathology,  physiology*
Kidney Diseases / physiopathology*
NADPH Oxidase / metabolism
Nitric Oxide Synthase Type I / metabolism
Nitric Oxide Synthase Type III / metabolism
Oxidative Stress
Physical Conditioning, Animal / physiology*
Rats, Inbred F344
Superoxide Dismutase / metabolism
Tyrosine / analogs & derivatives,  metabolism
Grant Support
Reg. No./Substance:
3604-79-3/3-nitrotyrosine; 55520-40-6/Tyrosine; 7722-84-1/Hydrogen Peroxide; EC Oxide Synthase Type I; EC Oxide Synthase Type III; EC protein, rat; EC Dismutase; EC Oxidase; EC protein, rat
Comment In:
J Physiol. 2011 Dec 15;589(Pt 24):5897   [PMID:  22174132 ]

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