| Twelve Weeks of Treadmill Exercise Does Not Alter Age-Dependent Chronic Kidney Disease in the Fisher 344 Male Rat. | |
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MedLine Citation:
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PMID: 21969451 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The aging kidney exhibits slowly developing chronic kidney disease (CKD) and is associated with nitric oxide (NO) deficiency and increased oxidative stress. The impact of exercise on the aging kidney is not well understood. Here, we determined whether 12 weeks of treadmill exercise can influence age-dependent CKD in old (22-24 months) Fisher 344 (F344) male rats by comparing sedentary (SED) and exercise (EX) trained rats; young (3 months) rats were also studied. In addition to renal structure and function, we assessed protein levels of various isoforms of the NO synthases (NOS) and superoxide dismutase (SOD) enzymes as well as markers of oxidative stress, in kidney cortex and medulla. Renal function as determined by plasma creatinine, proteinuria, and glomerular structural injury worsened with age and were unaffected by exercise. Aging also increased the protein abundance of neuronal (n)NOSβ and p22phox while decreasing extracellular (EC) and copper zinc (CuZn) SOD, in kidney cortex and medulla. H2O2 content and nitrotyrosine abundance also increased in the kidney with age. None of these age-related changes were altered with exercise. However, exercise did increase renal cortical eNOS and EC SOD in young rats. Data indicate that exercise-induced increases in eNOS and EC SOD seen in young rats are lost with age. We conclude that chronic exercise is ineffective in reversing age-dependent CKD in the male F344 rat. |
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Authors:
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Natasha C Moningka; Amy L Sindler; Judy M Muller-Delp; Chris Baylis |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-3 |
Journal Detail:
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Title: The Journal of physiology Volume: - ISSN: 1469-7793 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Physiology and Functional Genomics, University of Florida; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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