Document Detail

Tweaking biological switches through a better understanding of bistability behavior.
MedLine Citation:
PMID:  18804166     Owner:  NLM     Status:  MEDLINE    
Many biological events are binary. The switch between mutually exclusive OFF to ON state in response to a stimulus is frequently mediated by a control circuit with a positive and/or a negative feedback. Such a system typically exhibits hysteresis with its switching ON and OFF stimulus levels dependent on the current state of the system. The system can be shown to be bistable both experimentally and mathematically. Work to synthesize such switches by combining natural or engineered components has begun to illustrate the potential of such control circuits in many areas of applications.
Anushree Chatterjee; Yiannis N Kaznessis; Wei-Shou Hu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2008-10-01
Journal Detail:
Title:  Current opinion in biotechnology     Volume:  19     ISSN:  0958-1669     ISO Abbreviation:  Curr. Opin. Biotechnol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-11-21     Completed Date:  2009-01-08     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  9100492     Medline TA:  Curr Opin Biotechnol     Country:  England    
Other Details:
Languages:  eng     Pagination:  475-81     Citation Subset:  IM    
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MeSH Terms
Biological Clocks / physiology*
Computer Simulation
Computers, Molecular*
Feedback / physiology
Gene Expression Regulation / physiology*
Genetic Engineering / methods*
Metabolome / physiology*
Models, Biological*
Signal Transduction / physiology*
Grant Support

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