Document Detail

Tussigenic agents in the measurement of cough reflex sensitivity.
MedLine Citation:
PMID:  18204167     Owner:  NLM     Status:  MEDLINE    
Different inhalation methods are used for cough reflex sensitivity (CRS) measurement. The single-breath method of tussigenic agent aerosol inhalation is widely used now. Comparison of two tussigenic agents--citric acid and capsaicin--in cough reflex sensitivity measurement was used in healthy volunteers. In 17 healthy volunteers (7 M, 10 F; mean age 21 years) without respiratory tract infection in last 3 weeks, without cardiovascular, allergic, respiratory metabolic diseases, and with normal spirometry, cough reflex sensitivity was examined by nebuliser ProvoJet Ganshorn Medizin Elektronic, Germany) with doubled concentrations of capsaicin (SIGMA) from 0.49 to 1000 micromol/l and citric acid (LACHEMA) concentrations of 1, 3, 10, 30, 100, 300, 1000 micromol/l. Cough reflex sensitivity was defined as the lowest concentration of tussigenic agents which elicited 2 and 5 coughs (C2, C5). Geometric mean and 95% confidence interval (CI) of citric acid C2 was 454.5 (284.8-725.4) mmol/l in 88.2% of volunteers; citric acid C5 was 1000 micromol/l (0) in 47.1% of volunteers. Capsaicin C2 was 23.5 (8.2-67.5) micromol/l in 100% of volunteers and C5 was 263.7 (111.2-625.1) micromol/l in 76.5% of volunteers. We conclude that capsaicin single-breath test is more relevant for cough reflex sensitivity measurement in healthy volunteers than citric acid cough test.
R Pecova; N Javorkova; J Kudlicka; M Tatar
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  58 Suppl 5     ISSN:  0867-5910     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2008-01-21     Completed Date:  2008-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  531-8     Citation Subset:  IM    
Department of Pathological Physiology, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Slovakia.
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MeSH Terms
Capsaicin / adverse effects,  diagnostic use*
Citric Acid / adverse effects,  diagnostic use*
Cough / chemically induced*,  physiopathology*
Maximal Expiratory Flow Rate
Reflex / physiology*
Respiratory Function Tests
Vital Capacity / physiology
Reg. No./Substance:
404-86-4/Capsaicin; 77-92-9/Citric Acid

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