| Turnover of fatty acids in rat liver cardiolipin: comparison with other mitochondrial phospholipids. | |
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MedLine Citation:
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PMID: 1250068 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Following intraperitoneal administration of 1-14C-linoleic acid or 2-3H-acetate to rats, the specific radioactivities of both liver cardiolipin and other mitochondrial phospholipids after different time intervals were measured. Comparison of the data obtained with those from another stock of rats treated with 32P-phosphate or 2-3H-glycerol showed that the fatty acids of cardiolipin, like those of other phospholipids, exhibit an independent turnover with respect to the remaining parts of the molecule. The half-life of acyl moieties of cardiolipin is ca. 20% higher than that of the same components of other mitochondrial phospholipids. Moreover, it appears that, in both cardiolipin and other phospholipids, linoleyl residues turn over faster than nonessential fatty acids. Discussion is made as to whether this characteristic can be related to the role of phospholipids in the functioning of some enzymes bound to the inner mitochondrial membrane. |
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Authors:
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C Landriscina; F M Megli; E Quagliariello |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Lipids Volume: 11 ISSN: 0024-4201 ISO Abbreviation: Lipids Publication Date: 1976 Jan |
Date Detail:
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Created Date: 1976-04-15 Completed Date: 1976-04-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0060450 Medline TA: Lipids Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 61-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiolipins / metabolism* Linoleic Acids / metabolism* Male Mitochondria, Liver / metabolism* Phospholipids / metabolism* Rats Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Cardiolipins; 0/Linoleic Acids; 0/Phospholipids |
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