Document Detail

Turnover and excretion of copper in rats as measured with 67Cu.
MedLine Citation:
PMID:  3777163     Owner:  NLM     Status:  MEDLINE    
We have examined the whole-body turnover and excretion of copper in rats, using 67Cu. Female Fischer rats, 3-4 mo of age, were injected intraperitoneally with tracer doses of 67CuCl2, and whole-body radioactivity was monitored over the next 3-6 days. The rate of loss was exponential and biphasic, with a half-life of 67 h for the first 70 h, followed by a much slower rate over the following days. A small percentage (2-7%) of the early loss was in the urine, the rest in the feces. In sexually immature animals, turnover was slower in the first and faster in the second phases. Pretreatment of rats with a large dose of copper had no significant effect on the initial turnover rate. Ligation of the common bile duct cut the rate in half, but did not block turnover. It is concluded that there are at least two pools of copper in the rat that turn over at different rates and that excretion of copper occurs via the bile and also by other intestinal routes.
M C Linder; M Roboz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  251     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1986-12-12     Completed Date:  1986-12-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E551-5     Citation Subset:  IM    
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MeSH Terms
Bile / metabolism
Common Bile Duct / physiology
Copper / blood,  metabolism*,  urine
Kidney / metabolism
Liver / metabolism
Rats, Inbred Strains
Tissue Distribution
Grant Support
Reg. No./Substance:
0/Radioisotopes; 7440-50-8/Copper

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