Document Detail


Turning off sacral nerve stimulation does not affect gastric and small intestinal motility in patients treated for faecal incontinence.
MedLine Citation:
PMID:  22738022     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aim:  Sacral nerve stimulation (SNS) reduces symptoms in up to 80% of patients with faecal incontinence (FI). Its effects are not limited to the distal colon and the pelvic floor. Accordingly, spinal or supraspinal neuromodulation have been suggested as part of the mode of action. The effect of SNS on gastric and small intestinal motility was studied. Method:  Using the Magnet Tracking System MTS-1, a small magnetic pill was tracked twice through the upper gastrointestinal tract of eight FI patients successfully treated with SNS. With a randomized double-blind crossover design, the stimulator was either left active or turned off for one week before investigations with MTS-1. Results:  Median frequency of gastric contractions was 3.05 (2.83-3.40) min(-1) during SNS and 3.04 (2.79-3.76) min(-1) without SNS (ns). The median frequency of contractions in the small intestine during SNS was 10.12 (9.68-10.70) min(-1) and 10.07 (9.79-10.29) min(-1) without SNS (ns). The median velocity of the magnetic pill during the first two hours in the small intestine was 1.6 cm (1.2-2.8) min(-1) during SNS, and 1.6 cm (0.8-3.7) min(-1) without SNS (ns). Small intestinal propagation mainly occurred during very fast movements (> 15 cm min(-1) ) accounting for 51% (42-60%) of the distance in 3% (2-4%) of the time during SNS, and 53% (18-73%) of the distance in 3% (1-8%) of the time without SNS (ns). Conclusion:  Turning off SNS for one week did not affect gastric or small intestinal motility patterns. © 2012 The Authors Colorectal Disease © 2012 The Association of Coloproctology of Great Britain and Ireland.
Authors:
J Worsøe; J Fassov; V Schlageter; N J M Rijkhoff; S Laurberg; K Krogh
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-27
Journal Detail:
Title:  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland     Volume:  -     ISSN:  1463-1318     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883611     Medline TA:  Colorectal Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors Colorectal Disease © 2012 The Association of Coloproctology of Great Britain and Ireland.
Affiliation:
Department of Surgery P, Aarhus University Hospital, Aarhus, Denmark Center for Sensory-Motor Interaction (SMI), Department of Health Science and Technology, Aalborg University, Denmark Neurogastroenterology Unit, Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark Motilis Medica SA, Lausanne, Switzerland.
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