| Turning glucosuria into a therapy: Efficacy and safety with SGLT2 inhibitors. | |
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MedLine Citation:
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PMID: 20425568 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hyperglycemia is important in the development of microvascular and macrovascular complications from type 2 diabetes. Although there are many oral therapies available to help ameliorate hyperglycemia, it has been found that the competitive inhibition of the sodium-D-glucose cotransporter-2 (SGLT2) in the kidney may be a promising alternative treatment reducing hyperglycemia and potentially helping to lower the risk of diabetes complications. This article reviews clinical trials that have revealed favorable responses to many glycemic and metabolic parameters with SGLT2 inhibition, both as monotherapy and as an adjunct to insulin and oral antidiabetic agents. Additional studies are necessary to further determine the efficacy and long-term safety of SGLT2 inhibitors. |
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Authors:
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Anupa K Patel; Vivian Fonseca |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current diabetes reports Volume: 10 ISSN: 1539-0829 ISO Abbreviation: Curr. Diab. Rep. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-28 Completed Date: 2010-09-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101093791 Medline TA: Curr Diab Rep Country: United States |
Other Details:
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Languages: eng Pagination: 101-7 Citation Subset: IM |
Affiliation:
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Department of Endocrinology & Metabolism, Scott & White Hospital/Texas A&M Health Sciences Center, Temple, 76508, USA. akpatel@swmail.sw.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Clinical Trials as Topic Glycosuria / drug therapy* Humans Hyperglycemia / drug therapy Hypoglycemic Agents / adverse effects*, pharmacology, therapeutic use* Sodium-Glucose Transporter 2 / antagonists & inhibitors* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Hypoglycemic Agents; 0/Sodium-Glucose Transporter 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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