Document Detail


Turnabout is fair play: use of the bacterial Multivalent Adhesion Molecule 7 as an antimicrobial agent.
MedLine Citation:
PMID:  22086133     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pathogen attachment to host tissues is one of the initial and most crucial events during the establishment of bacterial infections and thus interference with this step could be an efficient strategy to fight bacterial colonization. Our recent work has identified one of the factors involved in initial binding of host cells by a wide range of Gram-negative pathogens, Multivalent Adhesion Molecule (MAM) 7. Interference with MAM7-mediated attachment, for example by pre-incubation of host cells with recombinant MAM7, significantly delays the onset of hallmarks of infection, such as pathogen-mediated cytotoxicity or the development of other adhesive structures such as actin pedestals. Thus, we are trying to develop tools based on MAM7 that can be used to prevent or diminish certain Gram-negative bacterial infections. Herein, we describe the use of bead-coupled MAM7 as an inhibitor of infection with the clinically relevant pathogen Pseudomonas aeruginosa.
Authors:
Anne Marie Krachler; Hyeilin Ham; Kim Orth
Related Documents :
21819223 - Micropatterned surfaces for reducing the risk of catheter-associated urinary tract infe...
21658173 - Internalization, phagolysosomal biogenesis and killing of mycobacteria in enucleated ep...
334273 - Enzyme immunoassay for the serodiagnosis of parasitic infections.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-01-01
Journal Detail:
Title:  Virulence     Volume:  3     ISSN:  2150-5608     ISO Abbreviation:  Virulence     Publication Date:    2012 Jan-Feb
Date Detail:
Created Date:  2012-03-27     Completed Date:  2012-09-07     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  101531386     Medline TA:  Virulence     Country:  United States    
Other Details:
Languages:  eng     Pagination:  68-71     Citation Subset:  IM    
Affiliation:
Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adhesins, Bacterial / genetics,  metabolism*,  pharmacology
Bacterial Adhesion / drug effects
Cell Line
Humans
Pseudomonas Infections / microbiology*
Pseudomonas aeruginosa / drug effects,  genetics,  physiology*
Grant Support
ID/Acronym/Agency:
R01 AI087808/AI/NIAID NIH HHS; R01-AI056404/AI/NIAID NIH HHS; R01-AI087808/AI/NIAID NIH HHS; R21 AI096133/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Adhesins, Bacterial
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Survival and control of Escherichia coli O157:H7 in foods, beverages, soil and water.
Next Document:  A first-principles description of proton-driven spin diffusion.