| Turnabout is fair play: use of the bacterial Multivalent Adhesion Molecule 7 as an antimicrobial agent. | |
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MedLine Citation:
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PMID: 22086133 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pathogen attachment to host tissues is one of the initial and most crucial events during the establishment of bacterial infections and thus interference with this step could be an efficient strategy to fight bacterial colonization. Our recent work has identified one of the factors involved in initial binding of host cells by a wide range of Gram-negative pathogens, Multivalent Adhesion Molecule (MAM) 7. Interference with MAM7-mediated attachment, for example by pre-incubation of host cells with recombinant MAM7, significantly delays the onset of hallmarks of infection, such as pathogen-mediated cytotoxicity or the development of other adhesive structures such as actin pedestals. Thus, we are trying to develop tools based on MAM7 that can be used to prevent or diminish certain Gram-negative bacterial infections. Herein, we describe the use of bead-coupled MAM7 as an inhibitor of infection with the clinically relevant pathogen Pseudomonas aeruginosa. |
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Authors:
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Anne Marie Krachler; Hyeilin Ham; Kim Orth |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-01-01 |
Journal Detail:
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Title: Virulence Volume: 3 ISSN: 2150-5608 ISO Abbreviation: Virulence Publication Date: 2012 Jan-Feb |
Date Detail:
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Created Date: 2012-03-27 Completed Date: 2012-09-07 Revised Date: 2013-02-20 |
Medline Journal Info:
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Nlm Unique ID: 101531386 Medline TA: Virulence Country: United States |
Other Details:
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Languages: eng Pagination: 68-71 Citation Subset: IM |
Affiliation:
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Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adhesins, Bacterial
/
genetics,
metabolism*,
pharmacology Bacterial Adhesion / drug effects Cell Line Humans Pseudomonas Infections / microbiology* Pseudomonas aeruginosa / drug effects, genetics, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI087808/AI/NIAID NIH HHS; R01-AI056404/AI/NIAID NIH HHS; R01-AI087808/AI/NIAID NIH HHS; R21 AI096133/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adhesins, Bacterial |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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