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Turbid plasma donations in whole blood donors: fat chance?
MedLine Citation:
PMID:  21382048     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Blood donations resulting in "nontransparent turbid milky" plasma must be discarded. The aim of this study was to objectively determine opacity and to identify risk factors for turbid plasma donations. STUDY DESIGN AND METHODS: This case-control study included 238 whole blood donors who provided turbid plasma (cases) and 309 random control subjects with normal plasma. Participants filled in a questionnaire regarding cardiovascular risk factors. Fat intake was assessed using a validated questionnaire. Opacity and lipids were measured. Additional data were retrieved from the blood bank information system. Mean differences and odds ratios were calculated with 95% confidence intervals. RESULTS: Cases had a less favorable cardiovascular profile compared to control subjects. The usual intake of fat was not associated with turbid plasma donation. In a multivariate model, having dinner before donation (OR, 4.9; 95% CI, 2.2-11.1), triglyceride levels (OR, 7.1; 95% CI, 4.6-10.8), and smoking (OR(yes vs. no) , 2.5; 95% CI, 0.9-6.7; and OR(ever vs. no) , 5.7; 95% CI, 1.8-18.4) were associated with an increased risk. Opacity was clearly increased in turbid plasma. Total cholesterol levels were 0.51 (95% CI, 0.35-0.66) mmol/L and triglyceride levels 4.28 (95% CI, 3.92-4.68) mmol/L higher in cases. High-density lipoprotein cholesterol levels were 0.34 (95% CI, -0.39 to -0.30) mmol/L lower. Forty-two percent of all cases had very high triglyceride levels (≥5.65 mmol/L) compared to less than 1% of control subjects. CONCLUSION: Donors who provided a turbid donation have a less favorable cardiovascular profile compared to other donors. Having dinner, high triglyceride levels, and smoking are independent risk factors for turbid plasma donations.
Authors:
Karlijn Peffer; Wim L A M de Kort; Ed Slot; Carine J M Doggen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-7
Journal Detail:
Title:  Transfusion     Volume:  -     ISSN:  1537-2995     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 American Association of Blood Banks.
Affiliation:
From the Sanquin Blood Bank Southeast Region, Nijmegen; and the Department of Health Technology and Services Research, School for Management and Governance, University of Twente, Enschede, The Netherlands.
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