Document Detail


Tuning and topography in an odor map on the rat olfactory bulb.
MedLine Citation:
PMID:  11160406     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The sense of smell originates in a diverse array of receptor neurons, comprising up to 1000 different types. To understand how these parallel channels encode chemical stimuli, we recorded the responses of glomeruli in the olfactory bulbs of the anesthetized rat, by optical imaging of intrinsic signals. Odor stimulation produced two kinds of optical responses at the surface of the bulb: a broad diffuse component superposed by discrete small spots. Histology showed that the spots correspond to individual glomeruli, and that approximately 400 of them can be monitored in this way. Based on its wavelength-dependence, this optical signal appears to derive from changes in light scattering during neural activity. Pure odorants generally activated several glomeruli in a bilaterally symmetric pattern, whose extent varied greatly with concentration. A simple formalism for ligand binding accounts quantitatively for this concentration dependence and yields the effective affinity with which a glomerulus responds to an odorant. When tested with aliphatic molecules of increasing carbon chain length, many glomeruli were sharply tuned for one or two adjacent chain lengths. Glomeruli with similar tuning properties were located near each other, producing a systematic map of molecular chain length on the surface of the olfactory bulb. Given local inhibitory circuits within the olfactory bulb, this can account for the observed functional inhibition between related odors. We explore several parallels to the function and architecture of the visual system that help interpret the neural representation of odors.
Authors:
M Meister; T Bonhoeffer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  21     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1351-60     Citation Subset:  IM    
Affiliation:
Harvard University, Cambridge, Massachusetts 02138, and Max Planck Institute of Neurobiology, D-82152 Munich-Martinsried, Germany. meister@biosun.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Aldehydes / administration & dosage
Animals
Brain Mapping / methods*
Dose-Response Relationship, Drug
Electron Transport Complex IV / metabolism
Female
Hemoglobins / metabolism
Image Processing, Computer-Assisted
Light
Odors
Olfactory Bulb / anatomy & histology*,  blood supply,  drug effects,  physiology*
Oxygen Consumption / physiology
Rats
Rats, Wistar
Receptors, Odorant / metabolism
Smell / drug effects,  physiology*
Stimulation, Chemical
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Aldehydes; 0/Hemoglobins; 0/Receptors, Odorant; EC 1.9.3.1/Electron Transport Complex IV

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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