| Tuning in to the ‘right’ calcium channel regulation in experimental models of diabetes. | |
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MedLine Citation:
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PMID: 20726982 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Elucidation of cellular and molecular mechanisms underlying vascular disease is of fundamental importance to the development of pharmacological agents to target these pathways. Pinho et al. in this issue of the BJP provide highly compelling evidence that the δ isoform of phosphatidyl inositol 3-kinase (PI3K δ) was upregulated and accounted for the increase in L-type, voltage-gated, Ca channel current in aortic vascular smooth muscle (VSM) cells of a mouse model of type 1 diabetes. There are several key issues of broad fundamental significance to this work. Firstly, what is the ‘right’ answer about calcium channel regulation in diabetes? Conflicting reports of increased and decreased Ca channel current may be due to specificity of the vascular bed and species. Then, the time course of diabetic vasculopathy may influence the expression of contractile versus proliferative phenotypes of VSM. Also the metabolic characterization of diabetes may enlighten or confound any study of diabetic vascular disease. These issues need attention to move forward work in this area. |
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Authors:
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M Sturek |
Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: British journal of pharmacology Volume: 161 ISSN: 1476-5381 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-29 Completed Date: 2011-05-18 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 1455-7 Citation Subset: IM |
Affiliation:
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Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202-5120, USA. msturek@iupui.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atherosclerosis / metabolism Calcium Channels, L-Type / metabolism* Clinical Trials as Topic Diabetes Mellitus, Experimental / metabolism* Humans Hyperglycemia / metabolism Male Mice Microvessels / physiopathology Muscle Contraction Muscle, Smooth, Vascular / metabolism Myocytes, Smooth Muscle / metabolism Vasodilation / physiology Wasting Syndrome / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channels, L-Type |
| Comments/Corrections | |
Comment On:
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Br J Pharmacol. 2010 Dec;161(7):1458-71
[PMID:
20942845
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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