| Tuning of apoptosis-mediator gene transcription in HepG2 human hepatoma cells through an adenosine signal. | |
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MedLine Citation:
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PMID: 19900759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Extracellular adenosine-induced apoptosis of HepG2 cells, a human hepatoma cell line, in a concentration (0.1-20mM)- and treatment (24-72h)-dependent manner by activating caspase-3, -8, and -9. In the gene expression assay using a DNA microalley, adenosine upregulated mRNAs for tumor necrosis factor (TNF), TNF receptor 1-associated death domain protein (TRADD), TNF related apoptosis-inducing ligand receptor 2 (TRAIL-R2), TRADD/receptor-interacting protein kinase 1 (RIPK1), Fas-associated death domain protein (FADD), and caspase-9, involving activation of caspase-8 and -9 followed by the effector caspase-3. The results of the present study suggest that adenosine induces HepG2 cell apoptosis by activating those caspases as a result from tuning apoptosis-mediator gene transcription. |
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Authors:
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Dongqin Yang; Takahiro Yaguchi; Chun-Ren Lim; Youhei Ishizawa; Takashi Nakano; Tomoyuki Nishizaki |
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Publication Detail:
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Type: Journal Article Date: 2009-11-08 |
Journal Detail:
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Title: Cancer letters Volume: 291 ISSN: 1872-7980 ISO Abbreviation: Cancer Lett. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-05 Completed Date: 2010-04-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 225-9 Citation Subset: IM |
Affiliation:
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Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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pharmacology* Apoptosis / drug effects, physiology* Carcinoma, Hepatocellular / genetics*, pathology Caspase 9 / drug effects, metabolism Caspases / drug effects, metabolism Cell Cycle / drug effects Cell Line, Tumor Cell Survival / drug effects Enzyme Activation Gene Expression Regulation, Neoplastic Humans Kinetics Liver Neoplasms / genetics*, pathology RNA, Messenger / genetics RNA, Neoplasm / genetics Receptors, Tumor Necrosis Factor / drug effects, physiology Transcription, Genetic* / drug effects Up-Regulation |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 0/RNA, Neoplasm; 0/Receptors, Tumor Necrosis Factor; 58-61-7/Adenosine; EC 3.4.22.-/Caspase 9; EC 3.4.22.-/Caspases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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