Document Detail

Tunica media remodeling in mesenteric arteries of hypertensive rats.
MedLine Citation:
PMID:  8888969     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The tunica media of the vascular wall is a composite material comprised of smooth muscle cells and fibrous and nonfibrous matrix proteins. METHODS: Using morphometric techniques, this study quantifies the cell and matrix composition of normotensive (Wistar-Kyoto) and spontaneously hypertensive rat mesenteric arteries. RESULTS: The data show that the superior mesenteric artery (SMA) and small mesenteric arteries are different in matrix composition, cell-to-matrix ratio, and cellular dense body content. Compared with normotensive arteries, hypertensive arteries have less basement membrane but more collagen and extracellular matrix ground substance. SMA from hypertensive rats has about 30% less elastin than does normotensive artery. In contrast, the elastin content of small arteries of both strains was about the same and was less than 4% of the matrix area. Except in hypertensive SMA, membrane dense bodies occupy 7-10% of the cell area and more than 10 times the area occupied by cytoplasmic dense bodies. In contrast, cells from hypertensive SMA have about half the membrane dense body area of the normotensive cells. A decreased proportion of dense bodies in the hypertensive SMA is consistent with the "partial detachment" of these cells from the matrix. CONCLUSIONS: These results are consistent with both cellular and matrix "remodeling" in diseased vessels in response to continuous, long-term elevated blood pressure.
L J McGuffee; S A Little
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Anatomical record     Volume:  246     ISSN:  0003-276X     ISO Abbreviation:  Anat. Rec.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-02-19     Completed Date:  1997-02-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370540     Medline TA:  Anat Rec     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  279-92     Citation Subset:  IM    
Department of Pharmacology, University of New Mexico School of Medicine, Albuquerque 87131-5316, USA.
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MeSH Terms
Cell Membrane / pathology
Collagen / metabolism
Cytoplasm / pathology
Elastin / metabolism
Endothelium, Vascular / pathology
Extracellular Matrix / metabolism
Hypertension / metabolism,  pathology*
Mesenteric Arteries / metabolism,  pathology*
Mesenteric Artery, Superior / metabolism,  pathology
Microscopy, Electron
Rats, Inbred SHR
Rats, Inbred WKY
Tunica Media / metabolism,  pathology*
Grant Support
Reg. No./Substance:
9007-34-5/Collagen; 9007-58-3/Elastin

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