| Tuned normalization explains the size of attention modulations. | |
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MedLine Citation:
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PMID: 22365552 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of attention on firing rates varies considerably within a single cortical area. The firing rate of some neurons is greatly modulated by attention while others are hardly affected. The reason for this variability across neurons is unknown. We found that the variability in attention modulation across neurons in area MT of macaques can be well explained by variability in the strength of tuned normalization across neurons. The presence of tuned normalization also explains a striking asymmetry in attention effects within neurons: when two stimuli are in a neuron's receptive field, directing attention to the preferred stimulus modulates firing rates more than directing attention to the nonpreferred stimulus. These findings show that much of the neuron-to-neuron variability in modulation of responses by attention depends on variability in the way the neurons process multiple stimuli, rather than differences in the influence of top-down signals related to attention. |
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Authors:
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Amy M Ni; Supratim Ray; John H R Maunsell |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuron Volume: 73 ISSN: 1097-4199 ISO Abbreviation: Neuron Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-27 Completed Date: 2012-04-16 Revised Date: 2013-04-15 |
Medline Journal Info:
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Nlm Unique ID: 8809320 Medline TA: Neuron Country: United States |
Other Details:
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Languages: eng Pagination: 803-13 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Attention / physiology* Brain Mapping Macaca mulatta Male Models, Neurological* Neurons / physiology* Orientation Photic Stimulation / methods Signal Processing, Computer-Assisted Space Perception / physiology* Visual Cortex / cytology*, physiology |
| Grant Support | |
ID/Acronym/Agency:
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R01 EY005911/EY/NEI NIH HHS; R01 EY005911-22/EY/NEI NIH HHS; R01 EY005911-23/EY/NEI NIH HHS; R01 EY005911-24/EY/NEI NIH HHS; R01 EY005911-24S1/EY/NEI NIH HHS; R01 EY005911-25/EY/NEI NIH HHS; R01 EY005911-26/EY/NEI NIH HHS; R01 EY005911-27/EY/NEI NIH HHS; R01 EY021550/EY/NEI NIH HHS; R01 EY021550-01/EY/NEI NIH HHS; R01 EY021550-02/EY/NEI NIH HHS; R01EY005911/EY/NEI NIH HHS; //Howard Hughes Medical Institute |
| Comments/Corrections | |
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