Document Detail


Tunable hydrogel-microsphere composites that modulate local inflammation and collagen bulking.
MedLine Citation:
PMID:  22659176     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Injectable biomaterials alone may alter local tissue responses, including inflammatory cascades and matrix production (e.g. stimulatory dermal fillers are used as volumizing agents that induce collagen production). To expand upon the available material compositions and timing of presentation, a tunable hyaluronic acid (HA) and poly(lactide-co-glycolide) (PLGA) microsphere composite system was formulated and assessed in subcutaneous and cardiac tissues. HA functionalized with hydroxyethyl methacrylate (HeMA) was used as a precursor to injectable and degradable hydrogels that carry PLGA microspheres (~50 μm diameter) to tissues, where the HA hydrogel degradation (~20 or 70 days) and quantity of PLGA microspheres (0-300 mgml(-1)) are readily varied. When implanted subcutaneously, faster hydrogel degradation and more microspheres (e.g. 75 mgml(-1)) generally induced more rapid tissue and cellular interactions and a greater macrophage response. In cardiac applications, tissue bulking may be useful to alter stress profiles and to stabilize the tissue after infarction, limiting left ventricular (LV) remodeling. When fast degrading HeMA-HA hydrogels containing 75 mgml(-1) microspheres were injected into infarcted tissue in sheep, LV dilation was limited and the thickness of the myocardial wall and the presence of vessels in the apical infarct region were increased ~35 and ~60%, respectively, compared to empty hydrogels. Both groups decreased volume changes and infarct areas at 8 weeks, compared to untreated controls. This work illustrates the importance of material design in expanding the application of tissue bulking composites to a range of biomedical applications.
Authors:
Elena Tous; Heather M Weber; Myung Han Lee; Kevin J Koomalsingh; Takashi Shuto; Norihiro Kondo; Joseph H Gorman; Daeyeon Lee; Robert C Gorman; Jason A Burdick
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-05-29
Journal Detail:
Title:  Acta biomaterialia     Volume:  8     ISSN:  1878-7568     ISO Abbreviation:  Acta Biomater     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-07-30     Completed Date:  2012-12-07     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  101233144     Medline TA:  Acta Biomater     Country:  England    
Other Details:
Languages:  eng     Pagination:  3218-27     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Collagen / metabolism*
Hydrogels*
Inflammation / therapy*
Male
Microspheres*
Models, Animal
Sheep
Grant Support
ID/Acronym/Agency:
EB008722/EB/NIBIB NIH HHS; HL63954/HL/NHLBI NIH HHS; HL73021/HL/NHLBI NIH HHS; R01 EB008722/EB/NIBIB NIH HHS; R01 HL063954/HL/NHLBI NIH HHS; R01 HL073021/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Hydrogels; 9007-34-5/Collagen
Comments/Corrections

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