Document Detail

Tumour-specific complement-dependent serum cytotoxicity against a chemically induced rat hepatoma.
MedLine Citation:
PMID:  197028     Owner:  NLM     Status:  MEDLINE    
A short-term 51Cr release test was used for the detection of complement-dependent cytolytic activity of syngeneic serum for transplanted aminoazo dye-induced rat hepatoma cells in suspension. Serum samples from rats bearing intraperitoneal implants of one hepatoma (hepatoma D23) were specifically cytotoxic for hepatoma D23 target cells, although this activity was not detected in sera from donors bearing subcutaneous tumour grafts. Other sera containing demonstrable IgG antibodies reactive in membrane immunofluorescence tests with individually distinct tumour-specific antigens or tumour-associated embryonic antigens were not cytotoxic for hepatoma D23 cells; and even though serum from donors carrying intraperitoneal tumour grafts contained tumour-specific IgG antibody, the complement-dependent reactivity was confined to the 19s region of fractionated tumour-bearer serum. These findings are discussed in relation to the development of humoral responses in the tumour-bearing host and with regard to the significance of the availability of an objective and reproducible assay for measuring humoral responses directed against the tumour-specific antigens associated with chemically induced rat tumours.
M R Price; R W Baldwin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  20     ISSN:  0020-7136     ISO Abbreviation:  Int. J. Cancer     Publication Date:  1977 Aug 
Date Detail:
Created Date:  1977-10-28     Completed Date:  1977-10-28     Revised Date:  2007-07-24    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  284-91     Citation Subset:  IM    
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MeSH Terms
Carcinoma, Hepatocellular / chemically induced,  immunology*
Complement System Proteins
Cytotoxicity Tests, Immunologic
Immune Sera
Liver Neoplasms / chemically induced,  immunology*
Neoplasms, Experimental / chemically induced,  immunology
Reg. No./Substance:
0/Immune Sera; 60-11-7/p-Dimethylaminoazobenzene; 9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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