Document Detail

Tumour shrinkage and down staging after preoperative radiation of rectal adenocarcinomas.
MedLine Citation:
PMID:  2193318     Owner:  NLM     Status:  MEDLINE    
In order to analyse the influence of low radiation doses on human rectal adenocarcinomas, gross and microscopical changes after preoperative radiation were compared to controls treated with immediate surgery in a randomised, prospective trial. The X-ray doses given were 31.5 Gy in 3.5 weeks, and the interval between radiation and operation was 2 to 3 weeks. A total of 138 patients having preoperative radiotherapy and 131 controls were analysed. The overall tumour size was reduced after radiation. Complete tumour regression was obtained in six (4.4%) patients. All of these tumours were exophytic and mobile at the initial examination and all were either well or moderately well differentiated. A significant downstaging was found after preoperative radiation. The incidence of positive lymph nodes was 27.5% in the resected specimens in controls and 18.4% after radiation (p less than 0.05). The total number of recurrences was reduced after radiation in stage C2 tumours, but not in the other stages. Preoperative radiation did not influence the histological grade of the tumours. There was no difference between the two randomised groups with respect to 5-year survival or disease-free survival in any histopathological stage.
A Horn; I Morild; O Dahl
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology     Volume:  18     ISSN:  0167-8140     ISO Abbreviation:  Radiother Oncol     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-07-31     Completed Date:  1990-07-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8407192     Medline TA:  Radiother Oncol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  19-28     Citation Subset:  IM    
Department of Surgery, Haukeland University Hospital, Bergen, Norway.
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MeSH Terms
Adenocarcinoma / mortality,  pathology,  radiotherapy*,  surgery
Aged, 80 and over
Follow-Up Studies
Middle Aged
Neoplasm Recurrence, Local
Neoplasm Staging
Prospective Studies
Radiotherapy Dosage
Randomized Controlled Trials as Topic
Rectal Neoplasms / mortality,  pathology,  radiotherapy*,  surgery
Survival Rate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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