| Tumour response prediction by diffusion-weighted MR imaging: Ready for clinical use? | |
| | |
MedLine Citation:
|
PMID: 22269446 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: The efficacy of anticancer therapy is usually evaluated by anatomical imaging. However, this method may be suboptimal for the evaluation of novel treatment modalities, such as targeted therapy. Theoretically, functional assessment of tumour response by diffusion weighted imaging (DWI) is an attractive tool for this purpose and may allow an early prediction of response. The optimal use of this method has still to be determined. METHOD: We reviewed the published literature on clinical DWI in the prediction of response to anticancer therapy, especially targeted therapy. Studies investigating the role of DWI in patients with cancer either for response prediction and/or response monitoring were selected for this analysis. RESULTS: We identified 24 studies that met our criteria. Most studies showed a significant correlation between (changes in) apparent diffusion coefficient (ADC) values and treatment response. However, in different tumours and studies, both high and low pretreatment ADC were found to be associated with response rate. In the course of treatment, an increase in ADC was associated with response in most cases. CONCLUSION: The potential of DWI for (early) response monitoring of anticancer therapies has been demonstrated. However, validation is hampered by the lack of reproducibility and standardisation. We recommend that these issues should be properly addressed prior to further testing the clinical use of DWI in the assessment of treatments. |
| | |
Authors:
|
Linda Heijmen; Maartje C H M Verstappen; Edwin E G W Ter Voert; Cornelis J A Punt; Wim J G Oyen; Lioe-Fee de Geus-Oei; John J Hermans; Arend Heerschap; Hanneke W M van Laarhoven |
Related Documents
:
|
21719256 - Quick detection of brain tumors and edemas: a bounding box method using symmetry. 22081446 - Computerized tomography scan facilitates the diagnosis of sacroiliitis in patients with... 17946576 - Segmentation of brain mr images using genetically guided clustering. 15670376 - Two-year follow-up of chronic stimulation of the posterior subthalamic white matter for... 18217336 - Carbon nanostructures as a new high-performance platform for mr molecular imaging. 20609876 - Ct angiography of the hepatic and pancreatic circulation. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-21 |
Journal Detail:
|
Title: Critical reviews in oncology/hematology Volume: - ISSN: 1879-0461 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8916049 Medline TA: Crit Rev Oncol Hematol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Department of Medical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hydrogen peroxide and monoethanolamine are the key causative ingredients for hair dye-induced dermat...
Next Document: Characterization of DNA methylation and its association with other biological systems in lymphoblast...