Document Detail


Tumour necrosis factor in the bronchoalveolar secretions of infants with the respiratory distress syndrome and the effect of dexamethasone treatment.
MedLine Citation:
PMID:  1539144     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Tumour necrosis factor alpha may contribute to the lung damage that occurs in the adult respiratory distress syndrome. Whether it occurs in the lungs of preterm infants with respiratory distress syndrome is unknown. METHODS: Tumour necrosis factor alpha concentrations in the bronchopulmonary secretions of 28 ventilated preterm infants were determined by the enzyme linked immunosorbent assay. RESULTS: Concentrations were low in the first three days of life, being undetectable in nine of the 20 infants whose bronchopulmonary secretions were sampled. From day 4 concentrations were increased and detectable in all but two of 14 infants. Similar concentrations were found in samples taken on days 8-20 and 21-40. Greater mean concentrations occurred in those infants requiring oxygen for a long time. In six infants who received dexamethasone treatment for prolonged ventilator dependency treatment was associated with a reduction in tumour necrosis factor alpha concentrations. CONCLUSIONS: Tumour necrosis factor may contribute to the neonatal respiratory distress syndrome, as suggested for the adult respiratory distress syndrome. The therapeutic effects of dexamethasone treatment in neonatal respiratory distress syndrome may be mediated, at least in part, by reduced production of pulmonary tumour necrosis factor.
Authors:
S H Murch; T T MacDonald; C B Wood; K L Costeloe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thorax     Volume:  47     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-04-02     Completed Date:  1992-04-02     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  44-7     Citation Subset:  IM    
Affiliation:
Academic Department of Child Health, Medical College St Bartholomew's Hospital, London.
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MeSH Terms
Descriptor/Qualifier:
Bronchoalveolar Lavage Fluid / immunology*
Dexamethasone / therapeutic use*
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / drug therapy,  immunology*
Respiratory Distress Syndrome, Newborn / drug therapy,  immunology*
Tumor Necrosis Factor-alpha / analysis*
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/Tumor Necrosis Factor-alpha; 50-02-2/Dexamethasone
Comments/Corrections

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