Document Detail


Tumour necrosis factor-alpha gene polymorphisms in asbestos-induced diseases.
MedLine Citation:
PMID:  20486865     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Tumour necrosis factor (TNF)-alpha influences the pathogenesis of lung fibrosis and carcinogenesis in normal cells. Polymorphisms of this gene have been suggested to be associated with susceptibility to lung diseases. METHODS: Association studies were performed in German subjects, using control subjects (n = 177), pulmonary fibrosis patients (n = 612) and bronchial carcinoma patients (n = 374). RESULTS: Compared with a healthy (control) group, a significant result could be obtained for the asbestosis (patient) group (crude odds ratio (OR(crude)) = 1.57; 95% confidence interval (CI) 1.05-2.36; p = 0.03), especially with severe lung asbestosis (OR(crude) = 4.15; 95% CI 1.06-16.16; p = 0.04). A significant association was revealed when comparing asbestosis patients (OR(crude) = 4.08; 95% CI 1.53-10.54; p = 0.004 and OR(adjusted) = 3.89; 95% CI 1.49-10.17; p = 0.006) with asbestos-induced lung cancer patients. CONCLUSION: The results confirm the hypothesis that TNF-alpha polymorphisms are associated with asbestos-induced fibrotic or malignant lung diseases in Germans.
Authors:
Simone Helmig; Nahid Aliahmadi; Joachim Schneider
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals     Volume:  15     ISSN:  1366-5804     ISO Abbreviation:  Biomarkers     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-20     Completed Date:  2010-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606000     Medline TA:  Biomarkers     Country:  England    
Other Details:
Languages:  eng     Pagination:  400-9     Citation Subset:  IM    
Affiliation:
Institut und Poliklinik für Arbeits- und Sozialmedizin, Justus-Liebig-Universität, Aulweg 129, D-35392 Giessen, Germany. Simone.Helmig@arbmed.med.uni-giessen.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Alleles
Asbestos
Carcinogens
Gene Frequency
Genetic Predisposition to Disease / genetics
Genotype
Germany
Humans
Lung Neoplasms / chemically induced,  genetics*
Middle Aged
Odds Ratio
Polymorphism, Single Nucleotide*
Promoter Regions, Genetic / genetics
Pulmonary Fibrosis / chemically induced,  genetics*
Risk Factors
Tumor Necrosis Factor-alpha / genetics*
Young Adult
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Tumor Necrosis Factor-alpha; 1332-21-4/Asbestos

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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