Document Detail

Tumour markers in colorectal cancer.
MedLine Citation:
PMID:  3201159     Owner:  NLM     Status:  MEDLINE    
Carcinoembryonic antigen (CEA) is still the best marker both for primary diagnosis and post-treatment monitoring of patients with colorectal cancer. Monoclonal antibodies, especially CA 19-9 and CA 50 may give additional information whereas CA 125 seems to be of no value in patients with colorectal cancer. The sensitivity of CEA determination for Dukes' A carcinomas is as low as 30%, but increases to 85% for Dukes' D carcinomas. The best clinical benefit of CEA is in postoperative monitoring of surgically treated patients with colorectal cancer. The sensitivity and specificity for distant metastases are 85%. The sensitivity in the detection of local recurrence is low (40%) but the specificity is still high (80%). A high CEA level postoperatively strongly suggests either local recurrence or disseminated disease, but a negative value does not exclude their presence. If CEA is negative both preoperatively and one month postoperatively, CA 19-9 or CA 50 may be used in the monitoring of these patients.
P J Roberts
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Scandinavian journal of gastroenterology. Supplement     Volume:  149     ISSN:  0085-5928     ISO Abbreviation:  Scand. J. Gastroenterol. Suppl.     Publication Date:  1988  
Date Detail:
Created Date:  1989-01-26     Completed Date:  1989-01-26     Revised Date:  2008-02-13    
Medline Journal Info:
Nlm Unique ID:  0437034     Medline TA:  Scand J Gastroenterol Suppl     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  50-8     Citation Subset:  IM    
University Central Hospital, Helsinki, Finland.
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MeSH Terms
Antibodies, Monoclonal / diagnostic use
Antigens, Tumor-Associated, Carbohydrate / analysis*
Carcinoembryonic Antigen / analysis*
Colorectal Neoplasms / diagnosis*
Postoperative Care
Tumor Markers, Biological / analysis*
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens, Tumor-Associated, Carbohydrate; 0/Carcinoembryonic Antigen; 0/Tumor Markers, Biological

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