Document Detail

Tumour invasion and metastasis: challenges facing drug discovery.
MedLine Citation:
PMID:  15955738     Owner:  NLM     Status:  MEDLINE    
Initial attempts at directly targeting metastatic spread using inhibitors of matrix metalloproteases failed to deliver the promise of anti-invasive therapy. A new generation of targeted agents with the potential to act as anti-invasives has recently entered the clinic but there is, as yet, no clear route to demonstrate an effect upon tumour metastasis. Because advances with monoclonal antibodies are likely to increase the number of potential anti-invasive agents, more clinically predictive drug discovery cascades are required to reduce the perceived risks associated with their generation. Once they reach the clinic, new approaches will be essential to help early indicators of clinical response meet ethical standards and avoid unnecessary clinical failures.
Paul Elvin; Andrew P Garner
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in pharmacology     Volume:  5     ISSN:  1471-4892     ISO Abbreviation:  Curr Opin Pharmacol     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-06     Completed Date:  2006-05-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966133     Medline TA:  Curr Opin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  374-81     Citation Subset:  IM    
AstraZeneca, Cancer and Infection Research Area, Mereside, Alderley Park, Macclesfield, SK10 4TG, UK.
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MeSH Terms
Drug Design*
Neoplasm Invasiveness / physiopathology,  prevention & control*
Neoplasm Metastasis / physiopathology,  prevention & control*
Neoplasms / drug therapy,  physiopathology
Technology, Pharmaceutical / methods,  trends

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