| Tumour growth and cancer therapy. | |
| | |
MedLine Citation:
|
PMID: 7437594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Tumour growth is the result of a complex balance between cell production and cell loss. The different rate of growth in different tumours depends on the extent to which this balance is tipped towards cell production. In some tumours most cells that are born contribute to the net growth, especially in fast-growing sarcomas. In other tumours very few of the tumour cells that are produced contribute to net growth, for example in slow-growing carcinomas. The kinetics of tumour cells is greatly influenced by the proliferation rate and pattern of branching of the capillary network supplying the tumour. These also influence the response to chemotherapy and to radiotherapy. In chemotherapy the kinetics of the tumour relative to the most rapidly growing cells anywhere in the body influences the potential therapeutic benefit that can be achieved. Radiotherapy depends on the relative kinetics and sensitivities of tumour and local normal tissues within the beam, including the tissue of origin. |
| | |
Authors:
|
J Denekamp |
Related Documents
:
|
9253164 - In vitro stimulation by tumour cell media of [3h]-thymidine incorporation by mouse sple... 19783044 - In vitro performance of an injectable hydrogel/microsphere based immunocyte delivery sy... 18396014 - Sebaceous carcinoma of the parotid gland in children: an immunohistochemical and ploidy... 3949254 - Behavioural pattern of tumour cells in mouse uterus. 19054764 - The cyclin-dependent kinase activator, spy1a, is targeted for degradation by the ubiqui... 22376274 - Recombinant production of the therapeutic peptide lunasin. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: British journal of hospital medicine Volume: 23 ISSN: 0007-1064 ISO Abbreviation: Br J Hosp Med Publication Date: 1980 Jun |
Date Detail:
|
Created Date: 1981-02-24 Completed Date: 1981-02-24 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0171545 Medline TA: Br J Hosp Med Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 566, 568, 570-1 passim Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Cycle Cell Survival Mitosis Neoplasms, Experimental / pathology*, radiotherapy* Rats |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A simple objective method for determining a dynamic journal collection.
Next Document: The bleeding patient.