Document Detail


Tumour-associated antigens, CEA, CA 125 and SCC in serum and follicular fluid of stimulated and unstimulated cycles.
MedLine Citation:
PMID:  8070597     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum and follicular fluid levels of CEA, CA 125 and SCC of women participating in an IVF program, in 42 cycles stimulated with GnRH-a and gonadotropins and in 26 unstimulated cycles triggered with HCG, were evaluated and compared with (a) steroid and gonadotropin levels, (b) the results of IVF, and (c) serum values in a control group of women with spontaneous normal ovulatory cycles. In the control group, serum antigens did not vary significantly during the 3 phases of the cycle. In stimulated cycles the median values in serum were 0.7 ng/ml (range, 0.0-2.1) for CEA, 14.0 U/ml (3.3-32.4) for CA 125 and 2.05 ng/ml (1.1-17.8) for SCC, whereas the median values in follicular fluid were 0.6 (0.0-27.9), 21.5 (0-670) and 21.4 (1-360), respectively. In unstimulated cycles the median values and ranges in serum were 0.9 (0.4-3.9), 12.1 (4.8-63.4) and 1.85 (0.7-4.4), respectively, whereas in follicular fluid they were 2.9 (0.4-180.7), 32 (1.7-600) and 231 (10.8-904). Different follicles of the same patients in stimulated cycles showed a wide divergence for all three antigens. In unstimulated cycles all three antigens in follicular fluid were strongly-correlated and a significant inverse correlation was observed between LH and both CA 125 and SCC in serum. In either group of cycles, no significant relationship was found between any serum or follicular fluid antigen and estradiol or testosterone, pregnancy rate, or oocyte quality and fertilization.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
I Phocas; A Sarandakou; D Rizos; F Dimitriadou; T Mantzavinos; P A Zourlas
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  54     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-09-27     Completed Date:  1994-09-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  131-6     Citation Subset:  IM    
Affiliation:
Second Department of Obstetrics and Gynecology, University of Athens, Areteion University Hospital, Greece.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, Neoplasm / analysis*,  blood
Antigens, Tumor-Associated, Carbohydrate / analysis*,  blood
Carcinoembryonic Antigen / analysis*,  blood
Embryo Transfer
Estrus
Female
Fertilization in Vitro
Follicular Fluid / chemistry*
Gonadal Steroid Hormones / analysis
Gonadotropins / analysis
Humans
Ovulation Induction*
Serpins*
Chemical
Reg. No./Substance:
0/Antigens, Neoplasm; 0/Antigens, Tumor-Associated, Carbohydrate; 0/Carcinoembryonic Antigen; 0/Gonadal Steroid Hormones; 0/Gonadotropins; 0/Serpins; 0/squamous cell carcinoma-related antigen

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