| Tumour assessment in advanced melanoma: value of FDG-PET/CT in patients with elevated serum S-100B. | |
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MedLine Citation:
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PMID: 17390135 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the usefulness of PET/CT in melanoma patients with an elevated serum S-100B tumour marker level. METHODS: Out of 165 consecutive high-risk melanoma patients referred for PET/CT imaging, 47 had elevated (>0.2 microg/l) S-100B serum levels and a contemporaneous 18F-FDG PET/CT scan. PET/CT scans were evaluated for the presence of metastases. To produce a composite reference standard, we used cytological, histological, MRI and PET/CT follow-up findings as well as clinical and S-100B follow-up. RESULTS: Among the 47 patients with increased S-100B levels, PET/CT correctly identified metastases in 38 (30 distant metastases and eight lymph node metastases). In one patient with cervical lymph node metastases, PET/CT was negative. Eight patients had no metastases and PET/CT correctly excluded metastases in all of them. Overall sensitivity for metastases was 97% (38/39), specificity 100% (8/8) and accuracy 98% (46/47). S-100B was significantly higher in patients with distant metastases (mean 1.93 microg/l, range 0.3-14.3 microg/l) than in patients with lymph node metastases (mean 0.49 microg/l, range 0.3-1.6 microg/l, p=0.003) or patients without metastases (mean 0.625 microg/l, range 0.3-2.6 microg/l, p=0.007). However, 6 of 14 patients with a tumour marker level of 0.3 microg/l had no metastases. CONCLUSION: In melanoma patients with elevated S-100B tumour marker levels, FDG-PET/CT accurately identifies lymph node or distant metastases and reliably excludes metastases. Because of the significant number of false positive S-100B tumour marker determinations (17%), we recommend repetition of tumour marker measurements if elevated S-100B levels occur before extensive imaging is used. |
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Authors:
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Klaus Strobel; Jeannine Skalsky; Victor Kalff; Katrin Baumann; Burkhardt Seifert; Helen Joller-Jemelka; Reinhard Dummer; Hans C Steinert |
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Publication Detail:
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Type: Journal Article Date: 2007-03-28 |
Journal Detail:
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Title: European journal of nuclear medicine and molecular imaging Volume: 34 ISSN: 1619-7070 ISO Abbreviation: Eur. J. Nucl. Med. Mol. Imaging Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-23 Completed Date: 2008-01-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140988 Medline TA: Eur J Nucl Med Mol Imaging Country: Germany |
Other Details:
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Languages: eng Pagination: 1366-75 Citation Subset: IM |
Affiliation:
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Division of Nuclear Medicine, Department of Medical Radiology, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland. klaus.strobel@usz.ch |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over False Positive Reactions Female Fluorodeoxyglucose F18 / pharmacology* Humans Male Melanoma / blood*, diagnosis, therapy* Middle Aged Neoplasm Metastasis Positron-Emission Tomography / methods* Tomography, X-Ray Computed / methods* Tumor Markers, Biological Whole Body Imaging |
| Chemical | |
Reg. No./Substance:
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0/Tumor Markers, Biological; 63503-12-8/Fluorodeoxyglucose F18 |
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