| Tumors induced in mice by N-methyl-N-formylhydrazine of the false morel Gyromitra esculenta. | |
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MedLine Citation:
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PMID: 628017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Continuous administration of 0.0078% N-methyl-N-formylhydrazine (MFH) in drinking water to 6-week-old outbred Swiss mice for life produced tumors of the liver, lung, gallbladder, and bile duct. The incidences of tumors in these four tissues were 33, 50, 9, and 7%, whereas in the untreated controls they were 1, 18, 0, and 0%, respectively. The higher dose (0.0156% MFH) given under identical conditions had no tumorigenic effect, since it proved too toxic for the animals. Histopathologically, the lesions were classified as benign hepatomas, liver cell carcinomas, adenomas and adenocarcinomas of the lungs, adenomas of the gallbladder, cholangiomas, and cholangiocarcinomas. Since the edible false morel Gyromitra esculenta contains a high amount of MFH, the human population should be dissuaded from consumption of this dangerous mushroom. |
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Authors:
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B Toth; D Nagel |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the National Cancer Institute Volume: 60 ISSN: 0027-8874 ISO Abbreviation: J. Natl. Cancer Inst. Publication Date: 1978 Jan |
Date Detail:
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Created Date: 1978-04-26 Completed Date: 1978-04-26 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7503089 Medline TA: J Natl Cancer Inst Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 201-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile Duct Neoplasms / chemically induced Carcinogens* Female Gallbladder Neoplasms / chemically induced Liver Neoplasms / chemically induced Lung Neoplasms / chemically induced Male Methylhydrazines / analogs & derivatives* Mice Monomethylhydrazine / analogs & derivatives*, toxicity Mushroom Poisoning / etiology* Neoplasms, Experimental / chemically induced* |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 0/Methylhydrazines; 60-34-4/Monomethylhydrazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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