| Tumorigenicity of 3'-hydroxymethyl, 3'-formyl, and 3'-carboxy derivatives of 4-(dimethylamino)azobenzene in rat liver. | |
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MedLine Citation:
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PMID: 6791985 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Male Sprague-Dawley rats were fed a cube diet containing 2.51 mmol/kg of 3'-methyl-4-(dimethylamino)azobenzene (3'-Me-DAB), 3'-CH2OH-DAB, 3'-CHO-DAB, or 3'-COOH-DAB (at a level equivalent to 0.06% 3'-Me-DAB in the diet) for a period of 1 to 3 months. Almost all the livers of rats given 3'-CH2OH-DAB for a period of 2 to 3 months or 3'-Me-DAB for 3 months showed marked cirrhosis macroscopically. The common histological findings were cholangiofibrosis with or without markedly atypical bile ducts. Moreover, one hepatocellular carcinoma was found in the liver of a rat given 3'-Me-DAB and one in the liver of a rat given 3'-CH2OH-DAB for 3 months. On the other hand, 3'CHO-DAB and 3'-COOH-DAB did not induce these changes (including neoplastic nodules) at all. Consequently, 3'-CH2OH-DAB, like 3'-Me-DAB, was found to be a hepatocarcinogen. |
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Authors:
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Y Mori; H Nagai; T Hori; T Niwa; K Toyoshi; A Koda; K Kawada; A Ojima |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Gann = Gan Volume: 72 ISSN: 0016-450X ISO Abbreviation: Gann Publication Date: 1981 Feb |
Date Detail:
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Created Date: 1981-11-18 Completed Date: 1981-11-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8214471 Medline TA: Gann Country: JAPAN |
Other Details:
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Languages: eng Pagination: 160-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight / drug effects Carcinogens* Diet Liver / pathology Liver Neoplasms, Experimental / chemically induced*, pathology Male Methyldimethylaminoazobenzene Organ Size / drug effects Rats Rats, Inbred Strains p-Dimethylaminoazobenzene / analogs & derivatives* |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 55-80-1/Methyldimethylaminoazobenzene; 60-11-7/p-Dimethylaminoazobenzene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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