Document Detail


Tumorigenic effect of some commonly used moisturizing creams when applied topically to UVB-pretreated high-risk mice.
MedLine Citation:
PMID:  18704106     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Irradiation of SKH-1 mice with UVB (30 mJ cm(-2)) twice a week for 20 weeks resulted in mice with a high risk of developing skin tumors over the next several months in the absence of further irradiation with UVB (high-risk mice). Topical applications of 100 mg of Dermabase, Dermovan, Eucerin Original Moisturizing Cream (Eucerin), or Vanicream once a day, 5 days a week for 17 weeks to these high-risk mice increased significantly the rate of formation of tumors and the rate of increase in tumor size per mouse. Additional studies indicated that treatment of high-risk mice with Dermabase, Dermovan, Eucerin, or Vanicream for 17 weeks increased the total number of histologically characterized tumors by 69% (average of two experiments; P<0.0001 in each experiment), 95% (P<0.0001), 24% (P<0.01), and 58% (P<0.0001), respectively. Topical applications of a specially designed Custom Blend cream to high-risk mice was not tumorigenic. The results indicate that several commercially available moisturizing creams increase the rate of formation and number of tumors when applied topically to UVB-pretreated high-risk mice. Further studies are needed to determine the effects of topical applications of moisturizing creams on sunlight-induced skin cancer in humans.
Authors:
Yao-Ping Lu; You-Rong Lou; Jian-Guo Xie; Qingyun Peng; Weichung J Shih; Yong Lin; Allan H Conney
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-08-14
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  129     ISSN:  1523-1747     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-16     Completed Date:  2009-02-27     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  468-75     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Animals
Emollients / pharmacology*
Female
Lipids / pharmacology
Mice
Mice, Hairless
Prevalence
Risk Factors
Skin Neoplasms / epidemiology,  etiology*
Sunlight / adverse effects
Ultraviolet Rays / adverse effects*
Water / pharmacology
Grant Support
ID/Acronym/Agency:
R01 CA114442/CA/NCI NIH HHS; R01 CA114442/CA/NCI NIH HHS; R01 CA114442-03/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Emollients; 0/Lipids; 059QF0KO0R/Water; 8036-49-5/eucerin
Comments/Corrections
Comment In:
J Invest Dermatol. 2009 Feb;129(2):515-6; author reply 517-8   [PMID:  19148221 ]
J Invest Dermatol. 2009 Sep;129(9):2316-8; author reply 2318-21   [PMID:  19809425 ]
J Invest Dermatol. 2009 Feb;129(2):513-4; author reply 514-5   [PMID:  19148219 ]
J Invest Dermatol. 2009 Feb;129(2):261-2   [PMID:  19148213 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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