| Tumorigenic effect of some commonly used moisturizing creams when applied topically to UVB-pretreated high-risk mice. | |
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MedLine Citation:
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PMID: 18704106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Irradiation of SKH-1 mice with UVB (30 mJ cm(-2)) twice a week for 20 weeks resulted in mice with a high risk of developing skin tumors over the next several months in the absence of further irradiation with UVB (high-risk mice). Topical applications of 100 mg of Dermabase, Dermovan, Eucerin Original Moisturizing Cream (Eucerin), or Vanicream once a day, 5 days a week for 17 weeks to these high-risk mice increased significantly the rate of formation of tumors and the rate of increase in tumor size per mouse. Additional studies indicated that treatment of high-risk mice with Dermabase, Dermovan, Eucerin, or Vanicream for 17 weeks increased the total number of histologically characterized tumors by 69% (average of two experiments; P<0.0001 in each experiment), 95% (P<0.0001), 24% (P<0.01), and 58% (P<0.0001), respectively. Topical applications of a specially designed Custom Blend cream to high-risk mice was not tumorigenic. The results indicate that several commercially available moisturizing creams increase the rate of formation and number of tumors when applied topically to UVB-pretreated high-risk mice. Further studies are needed to determine the effects of topical applications of moisturizing creams on sunlight-induced skin cancer in humans. |
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Authors:
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Yao-Ping Lu; You-Rong Lou; Jian-Guo Xie; Qingyun Peng; Weichung J Shih; Yong Lin; Allan H Conney |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2008-08-14 |
Journal Detail:
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Title: The Journal of investigative dermatology Volume: 129 ISSN: 1523-1747 ISO Abbreviation: J. Invest. Dermatol. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-16 Completed Date: 2009-02-27 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 468-75 Citation Subset: IM |
Affiliation:
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Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854-8020, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Animals Emollients / pharmacology* Female Lipids / pharmacology Mice Mice, Hairless Prevalence Risk Factors Skin Neoplasms / epidemiology, etiology* Sunlight / adverse effects Ultraviolet Rays / adverse effects* Water / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA114442/CA/NCI NIH HHS; R01 CA114442-03/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Emollients; 0/Lipids; 7732-18-5/Water; 8036-49-5/eucerin |
| Comments/Corrections | |
Comment In:
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J Invest Dermatol. 2009 Sep;129(9):2316-8; author reply 2318-21
[PMID:
19809425
]
J Invest Dermatol. 2009 Feb;129(2):515-6; author reply 517-8 [PMID: 19148221 ] J Invest Dermatol. 2009 Feb;129(2):513-4; author reply 514-5 [PMID: 19148219 ] J Invest Dermatol. 2009 Feb;129(2):261-2 [PMID: 19148213 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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